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AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2

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AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2

AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2
AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2 AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2 AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2

Large Image :  AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2

Product Details:
Place of Origin: China
Brand Name: ChineseHormone
Certification: ISO9001,SGS,UKAS
Model Number: CAS 2627-69-2
Payment & Shipping Terms:
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500g / month
Detailed Product Description
MF: C9H14N4O5 Skype: Amyyc9365
Solubility: 5 MM In DMSO, H2O Shipping: Ship With Blue Ice
Canonical SMILES: CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C Stored Desiccated: Below -20°C
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AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor CAS 2627-69-2

 

Cas No.

 

2627-69-2

SDF Download SDF

MF

 

C9H14N4O5

MW

 

258.23

Chemical Name

 

5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide

Canonical SMILES

 

CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

Chemical structure

AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2 0

Solubility

 

5 mM in DMSO, H2O: > 7 mg/mL Storage Store at -20°C

General tips

 

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

 

Shipping Condition

 

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

 

Description:

 

AICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK).

 

AMPK is a heterodimeric protein serine/threonine kinase that regulates the energy status of cells to protect cell from metabolic stress. AMPK phosphorylates various metabolic enzymes to activate catabolic pathways (e.g. ketogenesis) and block anabolic pathways (e.g. protein synthesis).

 

In rat primary astrocytes, microglia, and peritoneal macrophages, AICAR does-dependently inhibits the LPS-induced production of TNFα, IL-1β, and IL-6. AICAR treatment also blocks LPS-induced nitrite production and iNOS gene expression in those cells in a dose-dependent manner by activation of AMPK. Moreover, AICAR inhibits the LPS-induced C/EBP nuclear relocation via downregulating the expression of C/EBP-δ. [1]

 

In LPS-injected rats, AICAR treatment abolishes LPS-mediated increased levels of IL-1β and IFN-γ in serum. AICAR treatment also strongly inhibits the LPS-induced expression of iNOS in peritoneal macrophages isolated from these rats. Furthermore, the intraperitoneal injection of LPS significantly induces the expression of TNFα, IL-1β, and IFN-γ message in the rat spleen.

 

 

Reference:


1. Giri S, Nath N, Smith B et al. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci. 2004 Jan 14;24(2):479-87.

 

 

HPLC Condition:

 

AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2 1

 

 

Result:

 

AICAR (AMPK activator) AICA Ribonucleotide Anti-Tumor Inhibitor 50mg / vial CAS 2627-69-2 2

 

 

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