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Testosterone is a steroid hormone from the androgen group and is found in humans and other vertebrates. In humans and other mammals, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. Small amounts are also secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid.
In men, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate as well as promoting secondary sexual characteristics such as increased muscle, bone mass, and the growth of body hair. In addition, testosterone is essential for health and well-being as well as the prevention of osteoporosis.
On average, in adult males, levels of testosterone are about 7-8 times as great as in adult females. As the metabolic consumption of testosterone in males is greater, the daily production is about 20 times greater in men.Females are also more sensitive to the hormone.Testosterone is observed in most vertebrates. Fish make a slightly different form called 11-ketotestosterone. Its counterpart in insects is ecdysone.These ubiquitous steroids suggest that sex hormones have an ancient evolutionary history.
As a bodybuilding drug, testosterone is almost always used as an injectable ester, due to poor oral bioavailability and the impracticality of high dose transdermal or sublingual delivery. Testosterone also is provided as an injectable suspension. Discussion here is in reference to these injectable preparations.
Pharmacologically, testosterone acts both via the androgen receptor and via other means. In practice, it is found to combine synergistically both with those anabolic steroids categorized as Class I and those categorized as Class II, and therefore is described as having mixed activity.
If you really want to boost your natural testosterone levels, and receive all the benefits that come with it ie. greater muscle mass and strength, improved endurance, enhanced recovery etc. It is the most important product you will ever use!.
An anti-aromatase is preferable in a testosterone cycle to a selective estrogen receptor modulator (SERM) such as Clomid Nolvadex for controlling estrogen because the SERMs either do nothing towards reducing effect of elevated estrogen in aggravating or causing acne, or themselves contribute adversely. Additionally, abnormally elevated estrogen levels may be deleterious for other reasons.
With regard to inhibition of the hypothalamic/pituitary/testicular axis (HPTA), 200 mg/week of injected testosterone is approximately 2/3 to 3./4 suppressive, while 100 mg/week is about 50% suppressive. For this reason, low dose testosterone use is not particularly efficient, as natural production is already “worth” 100-200 mg/week, and this is mostly lost with the first 200 mg/week of injectable that is used. The particular synthetics which are low-suppressive are, for this reason, more efficient for low-dose use than is testosterone.
With use of an anti-aromatase, 600-750 mg/week of injected testosterone is a good dosage range for a novice. Without an anti-aromatase, it may be preferred to limit usage to 500 mg/week, although there can be risk of gynecomastia at doses even as low as 200 mg/week if no anti-estrogen is used. More advanced users may favor a gram per week. Still-higher doses such as 2 grams per week generally provide only a small further increment in performance, with that generally being noticeable only if a plateau has been reached at 1 gram per week. Amounts higher than this are employed by some pro bodybuilders but probably with only a slight further incremental effect.
For people who are worried about low or high testosterone, a doctor may perform a blood test to measure the amount of the hormone in the patient's blood. When doctors find low-T, they may prescribe testosterone therapy, in which the patient takes an artificial version of the hormone. This is available in the following forms: a gel to be applied to the upper arms, shoulders or abdomen daily; a skin patch put on the body or scrotum twice a day; a solution applied to the armpit; injections every two or three weeks; a patch put on the gums twice a day; or implants that last four to six months.
Men using testosterone gels must take precautions, such as washing hands and covering areas where the gel is applied, according to the U.S. Food and Drug Administration. Women and children should not touch the gel or the skin where the gel or patch is applied. In older men with true testosterone deficiencies, testosterone treatment has been shown to increase strength and sex drive, experts say.
But sometimes, symptoms of erectile dysfunction are due to other conditions, including diabetes and depression, according to the Mayo Clinic. Treating these men with testosterone hormone won't improve symptoms.
As a side effect, testosterone treatment lowers sperm count, so Michael A. Werner, a specialist in andropause, or "male menopause," recommends that men who desire future fertility avoid testosterone treatments. Other side effects include increased risk of heart problems in older men with poor mobility, according to a 2009 study at Boston Medical Center. The treatment can also increase the risk of sleep apnea, promote prostate and breast growth, and even encourage the development of prostate cancer, according to the Mayo Clinic.
With use of an anti-aromatase, 600-750 mg/week of injected testosterone is a good dosage range for a novice. Without an anti-aromatase, it may be preferred to limit usage to 500 mg/week, although there can be risk of gynecomastia at doses even as low as 200 mg/week if no anti-estrogen is used. More advanced users may favor a gram per week.
Still-higher doses such as 2 grams per week generally provide only a small further increment in performance, with that generally being noticeable only if a plateau has been reached at 1 gram per week.
Amounts higher than this are employed by some pro bodybuilders but probably with only a slight further incremental effect.
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