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Benzocaine Raw Powders for Local Anesthetic CAS 94-09-7

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Benzocaine Raw Powders for Local Anesthetic CAS 94-09-7

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Large Image :  Benzocaine Raw Powders for Local Anesthetic CAS 94-09-7

Product Details:
Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS 94-09-7
Payment & Shipping Terms:
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 kg / month
Detailed Product Description
Melting Point: 92 °C Water Solubility: 1310 Mg/L (at 30 °C)
Appearance: White Crystalline Powder Boiling Point: 310 °C
Usage: Local Anesthetic Shipment:: FedEx, TNT, EMS, DHL.UPS,EUB
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Benzocaine Raw Steroid Powders for Local Anesthetic CAS 94-09-7

 

Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.

 

Chemical properties

 

Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform and ethyl ether. The melting point of benzocaine is 88–90 °C, and the boiling point is about 310 °C.The density of benzocaine is 1.17 g/cm3.

 

History

 

Benzocaine was first synthesized in 1890 by the German chemist Eduard Ritsert (1859–1946),in the town of Eberbach and introduced to the market in 1902 under the name "Anästhesin".

 

Mechanism of action

 

Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential.

 

Uses

 

Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for:

  • Local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, toothache, sore gums, denture irritation)
  • Otic Pain (earache)
  • Surgical or procedural local anesthesia

 

Other uses

 

Benzocaine is used as a key ingredient in numerous pharmaceuticals:

  • Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.
  • Some previous diet products such as Ayds.
  • Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.
  • Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.
  • In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.
  • Benzocaine is commonly found, particularly in Britain, as an impurity in street cocaine and also as a bulking agent in "legal highs".Whilst giving a numbing effect similar to cocaine on users' gums it does not actually produce the effects of cocaine. Also benzocaine can and has been mistaken for a false positive for cocaine.
  • Benzocaine was used in synthesis of Leteprinim.

 

Experimental Properties

 

Property Value Source
melting point 92 °C PhysProp
boiling point 310 °C PhysProp
water solubility 1310 mg/L (at 30 °C) YALKOWSKY,SH & HE,Y (2003)
logP 1.86 HANSCH,C ET AL. (1995)
pKa 2.51 (at 25 °C) PERRIN,DD (1965)

 

Predicted Properties

 

Property Value Source
Water Solubility 2.85 mg/mL ALOGPS
logP 2.2 ALOGPS
logP 1.5 ChemAxon
logS -1.8 ALOGPS
pKa (Strongest Basic) 2.78 ChemAxon
Physiological Charge 0 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 1 ChemAxon
Polar Surface Area 52.32 Å2 ChemAxon
Rotatable Bond Count 3 ChemAxon
Refractivity 47.53 m3·mol-1 ChemAxon
Polarizability 17.46 Å3 ChemAxon
Number of Rings 1 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter Yes ChemAxon
Veber's Rule Yes ChemAxon
MDDR-like Rule Yes ChemAxon

 

 

Benzocaine Raw Powders for Local Anesthetic CAS 94-09-7 0

 

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