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|Appearance:||White Powder||Biological Half-life:||2.0-3.6 Hours|
|Bioavailability:||10-20% (first Pass Effect)||Trade Names:||Pulmicort, Rhinocort, Other|
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raw pharmaceutical materials
Budesonide Steroid Medication for Asthma and Chronic Obstructive Pulmonary Disease
Budesonide (BUD), sold under the brand name Pulmicort among others, is a steroid medication. It is available as an inhaler, pill, nasal spray, and rectal forms.The inhaled form is used in the long term management of asthma and chronic obstructive pulmonary disease (COPD).
The nasal spray is used for allergic rhinitis and nasal polyps. The pills in a delayed release form and rectal forms may be used for inflammatory bowel disease including Crohn's disease, ulcerative colitis and microscopic colitis.
Budesonide is nebulized for maintenance and prophylactic treatment of asthma including patients who require oral corticosteroids and those who may benefit from a systemic dose reduction.
Inflammatory bowel disease
Formulations of delayed-release Budesonide can be effective treatment for mild-to-moderately active Crohn's disease involving the ileum and/or ascending colon.A Cochrane review found evidence for up to 3 months (but not longer) of maintenance of remission Crohn's disease.
Budesonide assists in the induction of remission in people with active ulcerative colitis.
Nasal spray budesonide is a treatment for allergic rhinitis.
Budesonide may cause:
Budesonide is contraindicated as a primary treatment of status asthmaticus or other acute episode of asthma where intensive measures are required. It is also contraindicated for patients who have hypersensitivity to budesonide.
Mechanism of action
Those taking tablets or capsules orally should avoid grapefruit juice and echinacea.
Also, high fat meals delay absorption but do not impede absorption.
|Trade names||Pulmicort, Rhinocort, other|
|Molar mass||430.534 g/mol|
|Biological half-life||2.0-3.6 hours|
|Bioavailability||10-20% (first pass effect)|
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