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CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development

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CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development

CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development
CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development

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Product Details:
Place of Origin: China
Brand Name: Info@desen-nutrition.com
Certification: GMP,ISO9001,SGS,UKAS
Model Number: CAS 50-28-2
Payment & Shipping Terms:
Minimum Order Quantity: Free samples Available
Price: Negotiable
Packaging Details: Discreet package or as required
Delivery Time: 3-6 working days
Payment Terms: Western Union, MoneyGram, T/T,Bitcoins
Supply Ability: 500 kg / month
Detailed Product Description
Email: Info@desen-nutrition.com Whatsapp: 86-18908446193
Skype: Carrie.xiao96 Alias: β-estradiol
Packing: Discreet Packing For Customs Pass Guaranteed Catalogue: Sex Steroid Hormones
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Estradiol (abbreviated as E2), or 17β-estradiol, also known as estra-1,3,5(10)-triene-3,17β-diol, is a steroid and estrogen sex hormone, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles.

 

CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development

 

Estradiol Quick Detail:

 

Product name Estradiol
Other name Beta-Estradiol; B-estradiol; 17ß -Estradiol; β-estradiol; 1,3,5-estratriene-3,17beta-diol; 17beta-estradiol; 3,17beta-dihydroxy-1,3,5(10)-estratriene; dihydrofolliculin;
CAS 50-28-2
Einecs 200-023-8
MF C18H24O2
MW 272.382

 

 

Molecular Structure

CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development 0
Purity 99%
Appearance White crystalline powder
Usage Estradiol is essential for the development and maintenance of female reproductive tissues

 

Estradiol Descriptions:

Estradiol is essential for the development and maintenance of female reproductive tissues, but Estradiol also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.

 

Estradiol or œstradiol indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.

 

Estradiol is produced especially within the follicles of the female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone).

 

One principal pathway then converts progesterone to its 17α-hydroxy derivative, 17α-hydroxyprogesterone, and then to 4-androstenedione via sequential cytochrome P450-catalyzed oxidations.[citation needed] Action of aromatase on 4-androstenedione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.[citation needed] Alternatively, 4-androstenedione can be converted into the androgen, testosterone, which in turn can be converted directly into 17β-estradiol.

 

Estradiol Applications:

 

1. Sexual development

 

The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol produces breast development, and is responsible for changes in the body shape, affecting bones, joints, and fat deposition. Fat structure and skin composition are modified by estradiol.

 

2. Female reproduction

 

In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. Estradiol enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary.

 

During the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation.

 

3. Male reproduction

 

The effect of estradiol (and estrogens in general) upon male reproduction is complex. Estradiol is produced by action of aromatase mainly in the Leydig cells of the mammalian testis, but also by some germ cells and the Sertoli cells of immature mammals.

 

Estradiol functions (in vitro) to prevent apoptosis of male sperm cells. While some studies in the early 1990s claimed a connection between globally declining sperm counts and estrogen exposure in the environment, later studies found no such connection, nor evidence of a general decline in sperm counts. Suppression of estradiol production in a subpopulation of subfertile men may improve the semen analysis.

 

Males with certain sex chromosome genetic conditions, such as Klinefelter's syndrome, will have a higher level of estradiol.

 

4. Bone

 

Estradiol has a profound effect on bone. Individuals without it (or other estrogens) will become tall and eunuchoid, as epiphyseal closure is delayed or may not take place. Bone structure is affected also, resulting in early osteopenia and osteoporosis.

 

Also, women past menopause experience an accelerated loss of bone mass due to a relative estrogen deficiency.

 

5. Brain

 

Estrogens can be produced in the brain from steroid precursors. As antioxidants, they have been found to have neuroprotective function.

 

The positive and negative feedback loops of the menstrual cycle involve ovarian estradiol as the link to the hypothalamic-pituitary system to regulate gonadotropins.

 

6. Gynecological cancers

 

Estradiol has been tied to the development and progression of cancers such as breast cancer, ovarian cancer and endometrial cancer.

 

Estradiol has complex effects on the liver. In high amounts, it can lead to cholestasis. Estradiol affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood clotting.

 

Estrogen affects certain blood vessels. Improvement in arterial blood flow has been demonstrated in coronary arteries.

 

Several benign gynecologic conditions are dependent on estrogen, such as endometriosis, leiomyomata uteri, and uterine bleeding.

 

Estradiol COA:
 
TEST ITEMS SPECIFICATION RESULTS
Description White or Almost White Crystalline Powder white powder
Identification A.B. Positive
Assay 97.0~102.0% 99.3%
Specific Rotation +101°~+105° +102.6°
Loss On Drying 1.0%max 0.27%
Melting Point 153~157°C 153.0~155.0°C
Organic Volatile Impurities meets the requirement. Conforms
Related Substances meets the requirement. Conforms
Residual Solvents meets the requirement. Conforms
Particle Size 100% ≤ 20 microns Conforms
Conclusion The specification conform with USP30 standard

 

CAS 50-28-2 Estradiol Estrogen Sex Hormone β-estradiol For Sexual development 1

 

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