Home ProductsPharmaceutical Intermediates

Domperidone / Motilium Pharmaceutical Intermediates Stomach Disorders and Antiemetic

Certification
China Hengyang Desen Biotechnology Co., Ltd. certification
China Hengyang Desen Biotechnology Co., Ltd. certification
Customer Reviews
Awesome, thanks Irina. You've actually been the fastest and most responsive so far, you're going to be getting a lottt of business from me in future.

—— Andressa Hernandez from Brazil

EllenCaisin! I test the product, it is so good! Very happy. and I gave the treats to my family, you might be the best I ever used. best service!!!

—— Gabriel Collin from Canada

Aaron Fantastic! I have received the package. Thank you very much for great packaging. If it is good quality, you must have me as a long time customer

—— Mitch Kelly from USA

Yep Koala! got package thankyou so much, Koala. I like to place another order now. how much is T3 and tren a

—— Joaquin Vega from Spain

I'm Online Chat Now

Domperidone / Motilium Pharmaceutical Intermediates Stomach Disorders and Antiemetic

large.img.alt
small.img.alt small.img.alt

Large Image :  Domperidone / Motilium Pharmaceutical Intermediates Stomach Disorders and Antiemetic

Product Details:
Place of Origin: China
Brand Name: ChineseHormone
Certification: ISO9001,SGS,UKAS
Model Number: CAS 57808-66-9
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 KG / month
Detailed Product Description
Purity: 99% MW: 425.911
Appearance: White Powder Water Solubility: 0.0925 Mg/mL
MF: C22H24ClN5O2 Shipment: FedEx, TNT, EMS, DHL.UPS,EUB
High Light:

pharmaceutical raw material

,

raw pharmaceutical materials

 

Domperidone / Motilium Pharmaceutical Intermediates Stomach Disorders and Antiemetic

 

Domperidone (INN, USAN, BAN, JAN) (brand name Motilium, many others) is a peripherally selectivedopamine D2 receptor antagonist developed by Janssen Pharmaceutica that is used as an antiemetic,gastroprokinetic agent, and galactogogue. 

 

It may be administered orally or rectally, and is available in the form of tablets, orally disintegrating tablets (based on Zydis technology),suspension, and suppositories.The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation(breast milk production) by release of prolactin.

 

Mechanism of action

 

Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic:

 

The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting

 

Uses

 

This medication increases movement through the digestive system. It is used to treat symptoms of stomach disorders. It may also be used to prevent nausea and vomiting caused by certain medications. Due to safety concerns, this medication is not to be used by breast-feeding women to increase production of breast milk.

 

Domperidone / Motilium Pharmaceutical Intermediates Stomach Disorders and Antiemetic 0

 

How to use

 

Take this medication by mouth as prescribed usually 30 minutes before meals and at bedtime. Do not increase your dose or take this more often than directed. Your condition will not improve any faster but the risk of side effects will be increased.

 

Side effects

 

Headache, dizziness, dry mouth, nervousness, flushing, or irritability may occur the first several days as your body adjusts to the medication. Trouble sleeping, stomach cramps, hot flashes and leg crampshave also been reported.

 

If any of these effects continue or become bothersome, inform your doctor. Notify your doctor immediately if you develop: chest pain, slow/fast/irregular heartbeat, swelling of the feet or ankles, difficulty urinating, swelling of the breasts or discharge from the nipple in men or women, menstrual changes, sexual difficulties. If you notice other effects not listed above, contact your doctor or pharmacist.

 

Property Value Source
Water Solubility 0.0925 mg/mL ALOGPS
logP 3.7 ALOGPS
logP 2.9 ChemAxon
logS -3.7 ALOGPS
pKa (Strongest Acidic) 12.52 ChemAxon
pKa (Strongest Basic) 7.03 ChemAxon
Physiological Charge 1 ChemAxon
Hydrogen Acceptor Count 3 ChemAxon
Hydrogen Donor Count 2 ChemAxon
Polar Surface Area 67.92 Å2 ChemAxon
Rotatable Bond Count 5 ChemAxon
Refractivity 119.37 m3·mol-1 ChemAxon
Polarizability 45.61 Å3 ChemAxon
Number of Rings 5 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter Yes ChemAxon
Veber's Rule Yes ChemAxon
MDDR-like Rule Yes ChemAxon

 

Contact Details
Hengyang Desen Biotechnology Co., Ltd.

Contact Person: Sales Manager

Send your inquiry directly to us (0 / 3000)