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Exemestane Powder Anti Estrogen Steroids Aromasin For Breast Cancer CAS 107868-30-4

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Exemestane Powder Anti Estrogen Steroids Aromasin For Breast Cancer CAS 107868-30-4

China Exemestane Powder Anti Estrogen Steroids Aromasin For Breast Cancer CAS 107868-30-4 supplier
Exemestane Powder Anti Estrogen Steroids Aromasin For Breast Cancer CAS 107868-30-4 supplier Exemestane Powder Anti Estrogen Steroids Aromasin For Breast Cancer CAS 107868-30-4 supplier

Large Image :  Exemestane Powder Anti Estrogen Steroids Aromasin For Breast Cancer CAS 107868-30-4

Product Details:

Place of Origin: China
Brand Name: ChineseHormone
Certification: ISO9001
Model Number: 107868-30-4

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiation
Packaging Details: As your demand
Delivery Time: Within 12 hours After Payment
Payment Terms: T/T, Western Union, MoneyGram, BTC
Supply Ability: 100kg per month
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Detailed Product Description
Name: Exemestan/Aromasin CAS: 107868-30-4
Assay: 99% Powder: Yes
Shipping Policy: Free Sample Available Shipping Methods: EMS,HKEMS,FEDEX,DHL,TNT,Aramex,ETC
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Anti Estrogen Steroids Exemestane Powder Aromasin For Breast Cancer CAS 107868-30-4

 

Quick Details

 

Product name:  Exemestan/Aromasin
Chemical Name: 6-Methylenandrosta-1,4-diene-3,17-dione
CAS: 107868-30-4
Molecular formula: C20H24O2
Molecular Weight: 296.40
Appearance: White to almost white powder
Assay: 99.5%

 

Exemestane Description


Exemestanes Aromasin was first released on the U.S. market in 2000 after shortly gaining FDA approval a few months prior in 1999. The primary purpose of use as with most AI's would be to combat breast cancer in post-menopausal women. Shortly after, the AI would begin to gain a lot of popularity among anabolic steroid users for its ability to protect against estrogenic related side effects. This action is very similar to the older and more popular AI's in Arimidex and Femara It would also gain a fair amount of popularity in Post Cycle Therapy (PCT) plans among steroid users. It was not the first AI to gain such popularity but would prove to be a little more advantageous for this purpose than most AI's

Exemestanes Aromasin is officially classified as a steroidal suicide Aromatase Inhibitor, and carries the ability to inhibit the aromatase enzyme, which is responsible for the production or conversion of testosterone to estrogen. Aromasin has the ability to block aromatization, which in turn inhibits the production of estrogen, and thereby lowers the body's serum estrogen levels. This will prove useful to breast cancer patients as breast cancer often feeds off the estrogen hormone. It will also prove useful to the anabolic steroid user.


Exemestane Applications


Exemestanes Aromasin is used to fight breast cancer and raise testosterone in the body.
Exemestanes acetate blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestanes acetate can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.

 

How does Exemestane work?

 

Many breast cancers are stimulated by estrogen estrogen and progesterone. These breast carcinomas are known as hormone-sensitive or hormone-receptor-positive and can be treated with drugs that block the effects of these hormones.

 

In menopausal women, estrogen is produced primarily by converting androgen (an adrenal gonadotropin) to estrogen. This process is called aromatization, mainly in adipose tissue, muscle and skin. It requires a specific enzyme called an aromatase.

 

Exemestate has prevented the fragrance process. So it reduces the amount of estrogen in the body. In early breast cancer, taking exemestane can help prevent breast cancer recovery. In advanced breast cancer, cancer cells may grow slower or completely stop growing.

 

COA

 

TEST ITEMS SPECIFICATION RESULTS
Description White Crystalline Powder White Powder
Identification Positive Positive
Assay(by HPLC) 98.0~102.0% 98.64%
Absorbance(E1cm) 465~495 482.5
Melting Point 191~195ºC 193.5~195.0ºC
Loss On Drying 0.5%max 0.19%
Specific Rotation +288º~ +298º +290.2º
Residue On Ignition 0.1%max 0.03%
Related Substances Total:1.5%max <1.3%
  Single:0.5%max <0.4%
Residue Solvents 0.2%max 0.10%
Heavy Metals 20PPm max <10PPm
Conclusion The specification conform with enterprise standard.

 

Function and Use 

steroidal aromatase inactivator, whose structure is similar with natural substrate the androstenedione of aromatase, is the pseudosubstrate of aromatase.

As postmenopausal women's estrogen is mainly transferred under the effected by aromatase in peripheral tissues with androgen (produced in adrenal cortex), this product makes the aromatase inactive through combining the irreversible active site of aromatase, and hence to significantly reduce postmenopausal estrogen level in blood circulation.

This product had no obvious effect on adrenal cortical hormone biosynthesis, even if the concentration is higher than 600 times the effect of aromatase inhibition concentration, it has also no obvious effect on other enzymes in cortical hormone production.

Oral absorption of this product is rapid, and the oral bioavailability is 42%, which is influenced by the food. In postmenopausal women, the absorption rate of the drug is higher than that of the healthy subjects, and the peak concentration of blood drug is 2 ~ 4 hours after oral administration. The peak time is 1.2 hours, and is shorter than that of healthy subjects (2.9 hours).

The binding rate of total protein is 90%, which is mainly related to the α-acid glycoprotein and protein. Mainly through the liver metabolism, and the metabolite is inactive 17 - hydrogen exemestan, and elimination half-time is 24h. Primarily excreted by urine or feces, each accounting for 42% of the amount of dosis.

 

Our Advantage


1. Experience: We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;

2. Quality: Our company is a professional leading factory in China in pharmaceutical area, We had stable customers and exported to Germany, Spain, UK, USA, Australia, Middle East, and any other countries. We can provide good references about our company. As for the quality of the products, we 're sure they can satisfy you well enough;

3. Package: Professional packing with professional materials

4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.

 

Exemestane Powder Anti Estrogen Steroids Aromasin For Breast Cancer CAS 107868-30-4

 

Exemestane Powder Anti Estrogen Steroids Aromasin For Breast Cancer CAS 107868-30-4

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