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​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder

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​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder

​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder
​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder ​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder ​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder ​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder

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Product Details:
Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS 167933-07-5
Payment & Shipping Terms:
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 kg / month
Detailed Product Description
MW: 390.40 MF: C20H21F3N4O
Appearance: White Crystalline Powder Water Solubility: 0.178 Mg/mL
Alias: Addyi Shipment:: FedEx, TNT, EMS, DHL.UPS,EUB
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Flibanserin Medical Treatment for Female Hypoactive Sexual Desire Disorder

 

Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder drug by Sprout Pharmaceuticals.

 

Flibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters.

 

​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder 0

 

Medical uses

 

Flibanserin is used for hypoactive sexual desire disorder among women. Those receiving flibanserin report a 0.5 increase compared to placebo in the number of times they had “satisfying sexual events”. In those on flibanserin it rose from 2.8 to 4.5 times a month while women receiving placebo reported also an increase of “satisfying sexual events” from 2.7 to 3.7 times a month. 

 

The onset of the flibanserin effect was seen from the first timepoint measured after 4 weeks of treatment and maintained throughout the treatment period.The effectiveness of flibanserin was evaluated in three phase 3 clinical trials. Each of the three trials had two co-primary endpoints, one for satisfying sexual events (SSEs) and the other for sexual desire. Each of the 3 trials also had a secondary endpoint that measured distress related to sexual desire.

 

All three trials showed that flibanserin produced an increase in the number of SSEs and reduced distress related to sexual desire. The first two trials used an electronic diary to measure sexual desire, and did not find an increase. These two trials also measured sexual desire using the Female Sexual Function index (FSFI) as a secondary endpoint, and an increase was observed using this latter measure.

 

The FSFI was used as the co-primary endpoint for sexual desire in the third trial, and again showed a statistically significant increase.Women's overall feeling of improvement was small to none.The overall quality of the evidence was low.

 

​Flibanserin Medical Treatment Sex Steroid Hormones for Female Hypoactive Sexual Desire Disorder 1

 

Side effects

 

Adverse events are more common among women taking flibanserin. The majority of adverse events were mild to moderate. The most commonly reported adverse events included dizziness, nausea, feeling tired, sleepiness, and trouble sleeping.

 

Drinking alcohol while on flibanserin may result in severely low blood pressure (low blood pressure that produced symptoms occurred after only 2 glasses of wine occurred in 17%).

 

 

Flibanserin Flibanserin.svg
Trade names Addyi
Systematic (IUPAC) name 1-(2-{4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one
Formula C20H21F3N4O
Molar mass 390.40 g/mol
Bioavailability 33%
Protein binding 98%
Biological half-life 11 hours
Excretion Biliary (51%), kidney(44%)
Metabolism Extensive by liver(mainly by CYP3A4 andCYP2C19)

 

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