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Formestane CAS 566-48-3 99% Purity Raw Steroid Powders Formestane Hormone
Formestane is a second generation, irreversible, steroidal aromatase inhibitor. It inhibits the aromatase enzyme responsible for converting androgens to estrogens, thereby preventing estrogen production. Breast cancer may be estrogen sensitive or insensitive. A majority of breast cancers are estrogen sensitive. Estrogen sensitive breast cancer cells depend on estrogen for viability. Thus removal of estrogen from the body can be an effective treatment for hormone sensitive breast cancers. Formestanes has been targeted specifically for the treatment of postmenopausal women. Unlike premenopausal women who produce most estrogen in the ovaries, postmenopausal women produce most estrogen in peripheral tissues with the help of the aromatase enzyme. Formestanes, an aromatase inhibitor, can thus help to decrease the local production of estrogen by blocking the aromatase enzyme in peripheral tissues (ie. Adispose tissue of the breast) to treat hormone sensitive breast cancer.
Chemical Name: 4-Androsten-4,17β-ol-3-one
Molecular Formula: C19H28O3
Molecular weight: 304.42
Standard: Enterprise Standard
Product Categories:Pharmaceutical Raw Materials;Miscellaneous Biochemicals;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Anti-cancer&immunity
storage temp. 2-8°C
Chemical Properties Needles
Usage An antitumor drug. An aromatase inhibitor
Usage antineoplastic, aromatase inhibitor
Formestanes (Lentaron,4-hydroxyandrostenedione ) is a steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women.
Formestanes is often used to suppress estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor.
Formestanes has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified.
4-hydroxyandrostenedione significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer.
In comparative studies, the clinical efficacy of intramuscular (injected) formestanes 250mg did not differ significantly from that of oral megestrol when administered as second-line endocrine therapy to patients with advanced disease in whom previous tamoxifen therapy had failed.
Formestanes produced a response rate, duration of response and overall survival rate that was not significantly different from that of oral tamoxifen when administered as first-line endocrine therapy to patients with advanced disease, but tamoxifen was superior in some measures.
Formestanes Recommended Dosage
Formestanes was dosed at 100-200mgs per application. Users would apply it onto clean, dry skin and rub in thoroughly; usually on the thighs or upper arms. It took 1 to 5 minutes to dry.
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