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GBL Safe organic solvents Gamma Butyrolactone CAS 96-48-0 for Bodybuilding
Gamma Butyrolactone, 1, 4- Butyrolactone,
γ -Butyroladone, GBL, BLO
1.12 g/mL at 25 ° C(lit. )
Colourless oily liquid
Colorless clear oily liquid with acetone-like odor
Pharmaceutical Intermediates;Heterocycles;Miscellaneous Reagents
within 24 hours upon receipt of payment
Galvanied iron barrel,net weight:200kg±0.05
(1) GBL can be used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone , polyvinyl pyrrolidone, and α-Acetyl-γ-butyrolactone, etc.
(2)GBL can be used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the intermediate of vitamin and rolicyprine;
(3) GBL is the intermediate of plant growth stimulator and insecticide.
(4)GBL is a good antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent; Moreover, it can also be used in battery, capacitor and development of color film.
GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds.
These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.
GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB.
The hypnotic effect of GHB is enhanced by combination with alcohol. A 2003 rat study showed that GBL in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure was longer than both of the individual components combined
GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability.
Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.
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