Isotretinoin, is a medication primarily used to treat cystic acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.
Isotretinoin Drugs Pharmaceutical Intermediates CAS 4759-48-2 Roaccutane
Isotretinoin Quick Detail:
Synonyms:13-cis-retinoic acid; isotretinoin; Roaccutane
Usage :pharmaceutical raw materials, the hormone
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Isotretinoin Description :
Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments.Acne treatment usually begins with topical retinoids (e.g.tretinoin, adapalene), in combination with topical antibiotics (e.g. clindamycin, erythromycin) or antiseptics (e.g. benzoyl peroxide-containing preparations), followed by oral antibiotics (e.g. doxycycline or minocycline). In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications.
The dose of isotretinoin patients receive is dependent on their weight and the severity of the condition. High-dose treatments are administered between 0.5 mg/kg/day to 2 mg/kg/day (usually at 0.5 to 1 mg/kg/day, given as a single dose with food). Usually a course will last 8-10 months. A second course may be required. Efficacy appears to be related to the cumulative dose of isotretinoin taken, with a total cumulative dose over each course of 120-150 mg/kg used as a guideline.
Nearly all patients achieve initial clearing of acne during a normal course of isotretinoin therapy. 90% of patients achieve excellent clearance of their acne after a cumulative dose of 150 mg/kg.
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