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Hydrocortisone sodium succinate acts by controlling the rate of protein synthesis. It forms a steroid-receptor complex with receptor proteins, moves into the nucleus where it binds the chromatin and thus directs the genetic apparatus to transcribe RNA. It also delays the mineralocorticoid activity.
Medicine Pharmaceutical Intermediates Hydrocortisone sodium succinate CAS 125-04-2
Name: Hydrocortisone sodium succinate
Synonyms: HYDROCORTISONE HEMISUCCINATE SODIUM SALT;HYDROCORTISONE-HYDROGEN SUCCINATE SODIUM SALT;HYDROCORTISONE SODIUM SUCCINATE;HYDROCORTISONE 21-HEMISUCCINATE SODIUM;HYDROCORTISONE 21-HEMISUCCINATE SODIUM SALT;CORTISOL 21-HEMISUCCINATE SOD;CORTISOL 21-HEMISUCCINATE SODIUM-POTASSIUM SALT;CORTISOL 21-HEMISUCCINATE SODIUM SALT
As substitution therapy in the treatment of adrenal insufficiency states, where high levels of hydrocortisone are required rapidly.
In patients with known or suspected adrenal insufficiency prior to surgery, or if shock, severe trauma or other stress conditions occur.
Hydrocortisone sodium succinate is also used for the symptomatic relief of inflammatory conditions and as an immunosuppressant
Hypersensitivity to corticosteroids. Tuberculosis. Ocular herpes simplex. Primary glaucoma. Acute psychosis and psychoneurosis. Systemic infection. Peptic ulcer. Osteoporosis.
DOSAGE AND DIRECTIONS FOR USE:
Hydrocortisone sodium succinate is administered intravenously, intramuscularly or by intravenous infusion. The dose is 100 to 500 mg Hydrocortisone succinate given 3 to 4 times in 24 hours, dosage depending on the severity of the condition and the response.
Children up to 1 year may be given 25 mg, 1 to 5 years –50 mg and 6 to 12 years –100 mg.
Hydrocortisone sodium succinate may be administered in conjunction with suitable intravenous solutions, eg. Dextrose 5% and Sodium Chloride 0,9%, by intravenous infusion, in the desired volume of solution.
If reconstituted with the diluent provided, the solution is stable for 3 days.
The addition of Hydrocortisone sodium succinate to the solution for intravenous use should be made at the time of administration.
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