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The initial creation of the synthetic Melanotan-II peptide can be credited to the University of Arizona. During the course of research aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight.
Melanotan-II 10mg / Vial Bodybuilding Supplements Human Growth Peptides Skin Color
Melanotan-II Quick Detail:
Product name: Melanotan II
Molecular formula :C50H69N15O9
Molar mass: 1024.180
Category: peptide hormone , steroids Powder, alpha-Melanocyte stimulating hormone , Bodybuilding, MSH, Anabolic Steroids
The Development of Melanotan-II:
Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result.
Although this strategy exhibited promising results, Melanotan-II was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1 and Melanotan 2, which exhibit similar effects whilst possessing an extended half-life for functional therapeutic utilization.
Melanotan 2 Studies and Further Information:
Melanotan and Melanotan-II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan-II has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-II is a cyclic heptapeptide analog of the alpha-melanocyte stimulating hormone (a-MSH).
The effects of Melanotan-II on the diet and food intake of the laboratory mice have also been investigated.
Melanotan-II has been demonstrated that the central melanocortin (MC) has been activated by Melanotan-II when fed and induced in the mice. The six-day treatment of Melanotan-II has shown that the peptide actually reduced the body weight and the adipose tissue in the viscera of the mice and suppressed the caloric intake of the organism.
This has implications in clinical applications of the possible treatment to reduce carbohydrate or calorie intake especially for the overweight and the obese. Furthermore, the same study has also demonstrated that there was a sustained increase in the available oxygen consumption in obese animals. Melanotan 2 also helped reduced the level of serum insulin and the cholesterol levels when compared with the control treatments.
Furthermore, it has been suggested that Melanotan-II actually lowers the level of acetylcholine A caboxylase expression and even prevented the reduction of carnitine and palmitoltransferase I mRNA in muscle-type tissues by pair-feeding in the muscles of the obese rats.
Moreover, the Melanotan-II peptide actually increased the fat catabolism in the muscles and even improved the cholesterol metabolism (Li et al. 2004).
α-Melanocyte-Stimulating Hormone Analogues (Melanotan Peptides):
α-Melanocyte-stimulating hormone (α-MSH) is a naturally occurring endogenous melanotan peptide hormone of the melanocortin family, which is considered to be the most important of the melanocyte-stimulating hormones when it comes to stimulating melanogenesis, a process which in mammals is responsible for hair and skin pigmentation. α-MSH also plays a role in feeding behavior, energy homeostasis, and sexual activity (Bremelanotide and Melanotan-II). α-MSH is a nonselective agonist of melanocortin receptors MC1, MC3, MC4 and MC5. Melanotan 1 and Melanotan-II activate the MC1 receptor, which is responsible for effects on skin pigmentation.
Melanotan-II and PT-141 both stimulate the MC3 and MC4 receptors which are responsible for the regulation of appetite, metabolism, and sexual behavior. However, PT-141 Bremelanotide does not stimulate the MC1 receptor.
A few synthetic analogues of α-MSH have been investigated for their apparent photoprotective effects against ultraviolet (UV) radiation from the sun, namely Melanotan (afamelanotide) and Melanotan II, referred to as Melanotan-II. Bremelanotide, another analogue of α-MSH similar to Melanotan-II, is currently under development for the treatment of sexual dysfunction. All of these melanotan peptides have significantly greater potencies than α-MSH, but with distinctive selectivity peptide profiles.
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