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MT-1, Melanotan-1, 10mg/vial CAS: 75921-69-6 high purity 99% in stock

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MT-1, Melanotan-1, 10mg/vial CAS: 75921-69-6 high purity 99% in stock

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Large Image :  MT-1, Melanotan-1, 10mg/vial CAS: 75921-69-6 high purity 99% in stock

Product Details:
Place of Origin: China
Brand Name: ChineseHormone
Certification: ISO9001
Model Number: 75921-69-6
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiation
Packaging Details: As your demand
Delivery Time: Within 12 hours After Payment
Payment Terms: T/T, Western Union, MoneyGram, BTC
Supply Ability: 100kg per month
Detailed Product Description
Name: MT-1, Melanotan-1, CAS: 75921-69-6
Assay: 99% Pack: 10mg/vial
High Light:

muscle building peptides

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growth hormone peptides

 

MT-1, Melanotan-1, 10mg/vial CAS: 75921-69-6 high purity 99% in stock 

 

The initial creation of the Melanotan 1 peptide tanning analogue can be credited to the University of Arizona. During the course of study aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1, which exhibits similar effects whilst possessing an extended half-life for functional therapeutic utilization. The researchers, headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. They named this new peptide molecule "Melanotan" (later Melanotan-1).

 

Molecular formula: C78H111N21O19
Molar Mass: 1646.845
CAS: 75921-69-6
PubChem: CID 16154396
Synonyms: Melanotan; Melanotan-1; Melanotan I; CUV1647; EPT1647; NDP-MSH

 

TEST ITEMS SPECIFICATION RESULT
1 Appearence White powder Conforms
2 Peptide Content ≥80.0% 81.0%
3 Water (KF) ≤8.0% 5.8%
4 Acetic Acid 9%~15.0% 10.5%
5 Purity(HPLC) ≥98.0% 98.3

 

Sequence: Ac-NLE-c[ASP-His-d-PHE-ARG-TRP-LYS]-NH2 Chemical Bridge Asp2-Lys7
Cas No.: 121062-08-6
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.18
Purity (HPLC): 0.98
Appearance: White powder
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): >80.0%
Water Content(Karl Fischer): <8.0%
Acetate Content(HPIC): <10.0%
Specific Rotation (20/D): -55.0~-65.0°(c=1 1%HAc)
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Package: 10g/vial, 10vial/kit

 

COA:

 

Appearance White to off white powder Consistent
Purity(HPLC) ≥98% 99.10%
Water <6.0% 4.40%
Acetic Acid 3.0-8.0% 6.85%
Trifluoroacetic Acid <0.25% 0.18%
Peptide ≥80% 84.56%
MS Consistent Consistent

 

Melanotan-1 Mechanism of Action - How it Works!


Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.

 

Usage:

Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects.

Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.

MT-1(Melanotan I) Dosage

Start with a dose of 1mg daily for the first two or three days and, if level of side effects permit, look to increase dosage by 0.25mg every day over the next several days until you reach a daily dosage of 2-3mg. This level should be adequate for most users, though some may wish to increase yet further, perhaps as high as 5mg daily in order to achieve a very deep tan. A maintenance phase as described above is then used.

 

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MT-1, Melanotan-1, 10mg/vial CAS: 75921-69-6 high purity 99% in stock 0
 

Packing

Professional packing with professional materials, and We'll give clients several Packing way to choose after you contact me through my email

 

Quality

Our company is a professional leading factory in China in pharmaceutical area, ach batch of steroid powders have to tested by our QC(quality control) department before they are allowed to sell.

 

Delivery

We can pack your powders within 24 hours after your payment, and corresponding picture of your powders' parcel will be sent to you.

 

Price

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Payment

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Service

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