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Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs

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Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs

China Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs supplier
Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs supplier Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs supplier Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs supplier

Large Image :  Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs

Product Details:

Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS No 33069-62-4

Payment & Shipping Terms:

Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T.Bitcoin
Supply Ability: 500 kg / month
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Detailed Product Description
MW: 853.906 MF: C47H51NO14
Biological Half-life: 5.8 Hours Usage: Anti Cancer Drugs
Bioavailability: 6.5% (oral) Appearance: White Powder
Protein Binding: 89 To 98% Alias: Abraxane, Taxol, Onxol, Nov-Onxol
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Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs

 

What paclitaxel is?

 

Paclitaxel is a chemotherapy drug. It also known by its original brand name, Taxol. The drug is made from the needles of a particular type of yew tree. It works by stopping cancer cells separating into two new cells, so it blocks the growth of the cancer. It is a treatment for various types of cancer, including

 

  • Ovarian cancer

  • Breast cancer

  • Non small cell lung cancer.

  • AIDS related Kaposi's sarcoma

 

Sometimes it is combined with other anti cancer drugs.

One type of paclitaxel is combined with a protein called albumin to form a drug called Abraxane. Doctors also call it nab-paclitaxel. This drug tends to cause fewer side effects than other types of paclitaxel. It treats breast cancer that has spread and pancreatic cancer that has spread.

 

Medical use

 

Paclitaxel is approved in the UK for ovarian, breast and lung, bladder, prostate, melanoma, esophageal, and other types of solid tumor cancers as well as Kaposi's sarcoma. It is recommended in NICE guidance of June 2001 that it should be used for nonsmall cell lung cancer in patients unsuitable for curative treatment, and in first-line and second-line treatment of ovarian cancer.

 

In September 2001, NICE recommended paclitaxel should be available for the treatment of advanced breast cancer after the failure of anthracyclic chemotherapy, but that its first-line use should be limited to clinical trials. In September 2006, NICE recommended paclitaxel should not be used in the adjuvant treatment of early node-positive breast cancer. In 2005, its use in the United States for the treatment of breast, pancreatic, and non-small cell lung cancers was approved by the FDA.

 

Similar compounds

 

Albumin-bound paclitaxel (trade name Abraxane, also called nab-paclitaxel) is an alternative formulation where paclitaxel is bound to albumin nano-particles. Much of the clinical toxicity of paclitaxel is associated with the solvent Cremophor EL in which it is dissolved for delivery.Abraxis BioScience developed Abraxane, in which paclitaxel is bonded to albumin as an alternative delivery agent to the often toxic solvent delivery method.

 

This was approved by the U.S. Food and Drug Administration in January 2005 for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within six months of adjuvant chemotherapy.

 

Synthetic approaches to paclitaxel production led to the development of docetaxel. Docetaxel has a similar set of clinical uses to paclitaxel and is marketed under the name of Taxotere.

 

Recently the presence of taxanes including paclitaxel, 10-deacetylbaccatin III, baccatin III, paclitaxel C, and 7-epipaclitaxel in the shells and leaves of hazel plants has been reported. The finding of these compounds in shells, which are considered discarded material and are mass-produced by many food industries, is of interest for the future availability of paclitaxel.

 

Restenosis

 

Paclitaxel is used as an antiproliferative agent for the prevention of restenosis (recurrent narrowing) of coronary and peripheral stents; locally delivered to the wall of the artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.

 

Paclitaxel drug eluting coated stents for coronary artery placement are sold under the trade name Taxus by Boston Scientific in the United States. Paclitaxel drug eluting coated stents for femoropopliteal artery placement are sold under the trade name Zilver PTX by Cook Medical, Inc.

 

Paclitaxel Pharmaceutical Raw Powder Chemotherapy Drug Anti Cancer Drugs

 

Test items Quality index Test results
Appearance White crystalline powder White crystalline powder
Solubility Soluble in water and glacial acetic acid, almost not soluble in ethanol and acetone (96%) Soluble in water and glacial acetic acid, almost not soluble in ethanol and acetone (96%)
Identification Infrared absorption map complies with the tranexamic acid comparison map Infrared absorption map complies with the tranexamic acid comparison map
PH 7.0~8.0 7.24
  ≤0.5% 0.09%
Loss on drying
  ≤0.1% 0.01%
Residue on ignition
  ≤10ppm <10ppm
Heavy metals
  ≤0.1% <0.03%
Sulphate ash
  ≤140ppm <140ppm
Chloride
  99.0%~101.0% 99.95%
Assay
  A≤0.1%, B≤0.2% C≤0.1%, D≤0.1% A=0.043%, B=0.0608% C=0.0095%, D=0.0051%
Related substances Total impurities(except A,B) ≤0.2% Total impurities(except A,B)=0.015%
Conclusion Complies

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