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Pharmaceutical Raw Materials Anti-inflammatory Phenylbutazone CAS 50-33-9
|Product Categories:||Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Inhibitors;API;AZOLID|
Phenylbutazone, often referred to as "bute," is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals.
Phenylbutazone,In the United States and United Kingdom it is no longer approved for human use (except for ankylosing spondylitis, because no other treatment is available), as it can cause severe adverse effects such as suppression of white blood cell production and aplastic anemia. This drug was implicated in the 2013 meat adulteration scandal. Positive phenylbutazone tests in horse meat were uncommon in the UK, however.
Phenylbutazone is used occasionally in dogs for the longe-term management of chronic pain particularly due to osteoarthritis. About 20% of adult dogs are affected with osteoarthritis, which makes managing musculoskeletal pain a major component of companion-animal practice. There is a very narrow margin of safety for all NSAIDs in the dog and there are other NSAIDs that are used more commonly (etodolac and carprofen). GI-protectant drugs such as Misoprostol, cimetidine, omeprazole, ranitidine, or sucralfate frequently are included as a part of treatment with any NSAID. Dogs receiving chronic phenylbutazone therapy should be followed with regular blood work and renal monitoring.
Phenylbutazone is an inexpensive, generally well-tolerated drug. It frequently is the first choice for pain control of many musculoskeletal problems although other NSAIDs, such as flunixin, are used more commonly for gastrointestinal pain or colic. Recent research into NSAID toxicity and equine gastric ulcer disease may have given phenylbutazone a bad reputation for safety. However, when used at the appropriate dose and according to directions, phenylbutazone generally is a safe and effective drug. Additional care should be shown with special populations such as foals, ponies, older horses, and debilitated or dehydrated horses. These populations are more likely to have adverse side-effects.
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