Payment & Shipping Terms:
|Appearance:||White Crystalline Powder||Packing:||As Requirements|
pharmaceutical raw material,
raw materials for pharmaceutical products
Ibrutinib (Imbruvica) is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK), that is important in B cells; the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia, a form of non-Hodgkin's lymphoma.
Raw Pharmaceutical 99.9% Purity Ibrutinib For Treat B Cell Cancers CAS 936563-96-1
|Appearance||White Crystalline Powder|
|Application||1.Mantle cell lymphoma (MCL) who have received at least one prior therapy.
2.Chronic lymphocytic leukemia (CLL) who have received at least one prior therapy.
Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM.  PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).
Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease.
|Appearance||White to whitish crystal powder||Conforms|
|Loss on drying||NMT 0.5%||0.33%|
|Residue on ignition||NMT 0.1%||Conforms|
|Heavy metal||NMT 20ppm||Conforms|
|Assay (HPLC)||NLT 99.5%||99.77%|
|Related substances||NMT 0.5%||0.23%|
|Single impurity||NMT 0.1%||0.07%|
|Conclusion||Complies to the Enterprise standard.|
25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside.
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FAQ --- Order Guides:
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Xiaogan, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.
Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service
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A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!
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A: We accept all kinds of payment ways. such as alibaba trade asssurance, T/T, West union, Paypal.
Q7: Do you provide free sample?
A: Yes, we can provide free sample if we have in stock, just need you to cover the delivery cost.