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Sex Steroid Hormones for Premature Ejaculation Male Enhancement

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Sex Steroid Hormones for Premature Ejaculation Male Enhancement

Sex Steroid Hormones for Premature Ejaculation Male Enhancement
Sex Steroid Hormones for Premature Ejaculation Male Enhancement Sex Steroid Hormones for Premature Ejaculation Male Enhancement Sex Steroid Hormones for Premature Ejaculation Male Enhancement

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Product Details:
Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS 119356-77-3
Payment & Shipping Terms:
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 kg / month
Detailed Product Description
MW: 305.4134 Skype: Amyyc9365
MF: C21H23NO Protein Binding: >99%
Half Life: 1-2 Hours. Shipment: FedEx, TNT, EMS, DHL.UPS,EUB
High Light:

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Sex Steroid Hormones for Premature Ejaculation Male Enhancement

 

CAS number:119356-77-3

WeightAverage: 305.4134
Monoisotopic: 305.177964363

Chemical Formula:C21H23NO

Half lifeInitial half-life:1-2 hours.

Chemical structure:

Sex Steroid Hormones for Premature Ejaculation Male Enhancement 0
, marketed as and Westoxetin, among and other brands, is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18–64 years old. works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay.

 

As a member of selective serotonin reuptake inhibitor (SSRI) family, was initially created as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

 

Originally created by Eli Lilly pharmaceutical company, was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. has been sold in several European and Asian countries, and lately in Mexico. In the US, has been stuck in phase III development since 2003. However, it is expected to be marketed soon.In 2012, Menarini acquired the rights to commercialise in Europe, most of Asia, Africa, Latin America and the Middle East.

 

Therapeutic uses


Premature ejaculation

 

Randomized, double blind, placebo-controlled trials have confirmed the efficacy of for the treatment of PE.Different dosage has different impacts on different type of PE. 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. , given 1–3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE.

 

Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used.[9] However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction., on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug's accumulation in the body, and therefore reducing side effects.

 

Predicted Properties

 

Water Solubility 0.000837 mg/mL ALOGPS
logP 4.75 ALOGPS
logP 4.67 ChemAxon
logS -5.6 ALOGPS
pKa (Strongest Basic) 9.04 ChemAxon
Physiological Charge 1 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 12.47 Å2 ChemAxon
Rotatable Bond Count 6 ChemAxon
Refractivity 96.14 m3·mol-1 ChemAxon
Polarizability 35 Å3 ChemAxon
Number of Rings 3 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter Yes ChemAxon
Veber's Rule Yes ChemAxon
MDDR-like Rule Yes ChemAxon

 

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