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SYN-AKE 823202-99-9 Pharmaceutical Intermediates White Powder Hair Loss Treatment Powder

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SYN-AKE 823202-99-9 Pharmaceutical Intermediates White Powder Hair Loss Treatment Powder

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Large Image :  SYN-AKE 823202-99-9 Pharmaceutical Intermediates White Powder Hair Loss Treatment Powder

Product Details:
Place of Origin: China
Brand Name: ChineseHormone
Certification: ISO9001,SGS,UKAS
Model Number: CAS:823202-99-9
Payment & Shipping Terms:
Minimum Order Quantity: Free samples Available
Price: Negotiable
Packaging Details: Discreet package or as required
Delivery Time: 3-6 working days
Payment Terms: T/T, Western Union, MoneyGram,BItcoins
Supply Ability: 500 kg / month
Detailed Product Description
Assay: >95% Character: White Powder
Grade: Pharmaceutical Grade Packing: Discreet Ways Of Packing For Customs Pass Guaranteed
High Light:

pharmaceutical raw material

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raw materials for pharmaceutical products

SYN-AKE 823202-99-9 Pharmaceutical Intermediates White Powder Hair Loss Treatment Powder

 

CAS No.: 823202-99-9

Type: Vitamins, Amino Acids and Coenzymes

Product : SYN-AKE 823202-99-9

General name: SYN-AKE

INCI name: Dipeptide diaminobutyroyl benzylamide diacetate

Appearance: White dry-freezing powder

Molecular Formula: C19H29N5O3.2(C2H4O2)

Molecular Weight: 495.58

Function: anti-wrinkle

Application: Cosmetics (mask ,cream )

Purity: >98%

Water:not more than 10%

Acetic acid:not more than 15%

Certification:MSDS&COA

Sample:Available

 

Introduction:


YScpAKE is a small peptide that simulates the activity of Waglerin I in snake venom toxin. Clinical trials have shown that snake venom can reduce wrinkles by suppressing muscle contraction and has excellent smooth and rapid wrinkle properties.

 

A new antiwrinkle active compound based on a synthetic tripeptide that mimics the effect of Waglerin 1,a peptide that is found in the venom of the Temple Viper, Tropidolaemus wagleri.

 

Product Name: (2S)-beta-Alanyl-L-prolyl-2,4-diamino-N-(phenylmethyl)butanamide acetate
Synonyms: (2S)-beta-Alanyl-L-prolyl-2,4-diamino-N-(phenylmethyl)butanamide acetate;SYN-AKE;snake-tripeptide;H-β-Ala-Pro-Dab-NHBzl.2AcOH;Snake trippetide;Dipeptide Diaminobutyroyl Benzylamide Diacetate
CAS: 823202-99-9
MF: C19H29N5O3.2(C2H4O2)
MW: 495.58
Appearance: White powder
Mol File: 823202-99-9.mol
(2S)-beta-Alanyl-L-prolyl-2,4-diamino-N-(phenylmethyl)butanamide acetate Structure

 

Mechanism:


YScpAKE is a potent smooth and fouling active product that relaxes facial muscles and is consistent with the neuromuscular blockade compound Waglerin 1 of Temple Viper venom venom. YScpAKE (a snake-like tripeptide) acts on the postsynaptic membrane and is an antagonist of muscle nicotinic acetylcholine receptor (nmAChR) reversible. YScpAKE (serpentine tripeptide) binds to the? Subunit of nmAChR to block the binding of acetylcholine to the receptor, eventually leading to receptor closure, in the closed state of sodium can not be ingested, can not depolarize, nerve excitatory transmission block, The muscles are so loose.


Clinical testing:


The culture of cultured muscle cells showed that the use of 250 PPM YScpAKE (snake-like tripeptide) reduced muscle contraction by 36% after one minute and 82% after 2 hours, so snake venom could be used as an immediate wrinkle product.


YScpAKE (snake venom tripeptide) wrinkle determination:


Fifty subjects were involved in this study, and the YScpAKE (serotonin) was used in combination with placebo and reference substance. The trial lasted 28 days twice a day. The results showed that YScpAKE (serotonin tripeptide) significantly reduced the expression of the forehead, and the YScpAKE (serotonin) was significantly more active than the reference substance acetyl hexapeptide-8.

The raw material is a solution or a pure peptide


YScpAKE (serpentine tripeptide) solution


INCI Name: Water, Glycerin, Tripeptide
Appearance: transparent colorless to yellow viscous liquid
Content: 2000 ~ 3000ppm
PH: 4.5 to 5.5
Microbiological count: <100CFU / ml
Specific pathogens none

YScpAKE (serpentine tripeptide) pure peptide
Appearance: white crystal

Storage and shelf life
YScpAKE (venom-like tripeptide) solution must be stored in a cool, dark and clean place to ensure a shelf life of at least 12 months. Long-term storage, recommended storage at 4 ° C, shelf life can be extended to at least 18 months.
YScpAKE (serpentine tripeptide) pure peptide, recommended stored at 2-8 ° C, shelf life of 24 months.

 

Safety:


In vitro and in vivo tests showed that the three peptides did not show any cytotoxicity, skin irritation, allergies and eye irritation

 

Application of liquid and recommended dosage:


Add cosmetic, such as lotions, gels, etc. in cosmetic formulations to achieve the desired effect of removing deep wrinkles or wrinkles around the forehead or eyes. Add 5% stock solution to the final stage of cosmetic production

 

Certificate of Analysis (COA) for SYN-AKE:

 

Product Name SYN-AKE
CAS.NO. 823202-99-9 Sequence or Structure
Molecular Formula C19H29N5O3

 

 

Β-Ala-Pro-Dab-NH-Bzl·HOAc

Molecular Weight 375.47
Batch No. 20170401
Production Date 20170420
Retest Date 20190419
Storage Sealed, dry, avoid light preservation, 2-8℃.
Specification and certificate of Analysis
Test Items Standards Results
Appearance White to yellowish Powder Off-White Powder
Identification(MS) 375.23±1 376.2(M+1)
Purity(HPLC) ≥95.0% 97.20%
Impurities(HPLC) ≤5.0% 2.80%
Peptide Content(N) ≥80.0% 81.30%
Acetate(HPLC) ≤15.0% 12.10%
PH(1% Water Soln.) 3.0-6.0 5.35
Water(KF) ≤8.0% 3.80%
Solubility ≥100mg/ml(H2O) Confirms
Conclusion Meets Standard

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Hengyang Desen Biotechnology Co., Ltd.

Contact Person: Sales Manager

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