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Toremifene Citrate Powder selective estrogen receptor modulator For breast cancer treatment CAS: 89778-27-8
Toremifene Citrate Quick Details:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. Toremifene citrate is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
|Product Name||Toremifene citrate|
|Appearance||White Crystalline Powder|
Toremifene Citrate Descriptions:
In 2007 the pharmaceutical company GTx, Inc was conducting two different phase 3 clinical trials; First, a pivotal Phase clinical trial for the treatment of serious side effects of androgen deprivation therapy (ADT) (especially vertebral/spine fractures and hot flashes, lipid profile, and gynecomastia) for advanced prostate cancer, and second, a pivotal Phase III clinical trial for the prevention of prostate cancer in high risk men with high grade prostatic intraepithelial neoplasia, or PIN. Results of these trials are expected by first quarter of 2008.
An NDA for the first application (relief of prostate cancer ADT side effects) was submitted in Feb 2009, and in Oct 2009 the FDA said they would need more clinical data, e.g. another phase III trial.
Toremifene Citrate COA:
|Description||White or Almost White Crystalline Powder||White Powder|
|Loss On Drying||0.5%max||0.25%|
|Organic Volatile Impurities||meets the requirments.||Conforms|
|Residual Solvents||meets the requirments.||Conforms|
|Conclusion||The specification conform with USP32 standard|
Toremifene Citrate Applications:
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there.
Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.
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Can be used as pharmaceutical material
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