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Rimonabant (also known as SR141716; trade names Acomplia, Zimulti) is an anorectic antiobesity drug. Rimonabant is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil.
Weight Loss Drug Rimonabant CAS 168273-06-1 For Reduceing Weight
Product name: Rimonabant
How does Rimonabant work?
Rimonabant acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle2.
Rimonabant switches off the same brain circuits that make people hungry when they smoke cannabis.
CB1 receptor blockade with Rimonabant acts to decrease the overactivity of the endocannabinoid system (EC system).3,4 The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism.
What is Rimonabant used for?
Rimonabant was studied to be used complementary to diet and exercise to treat obese or overweight patients who suffer from type 2 diabetes and abnormal levels of fat in the blood.
Sanofi argued that Rimonabant could also prevent the risk of cardiovascular disease.
Patients with large waist circumference (102 cm in men and 88 cm in women) were said to most benefit from taking the drug.
Rimonabant as a new weight loss drug, can also be used to quit smoking. Not only lose weight, but also lower blood pressure, cholesterol and blood sugar, clinical study found that subjects taking one to two months later, the weight can be reduced on average six to eight kilograms.
|Name||Molecular Formula||Formula Weight||CAS|
|Kidney Bean Extract||N/A||N/A||85085-22-9|
|Picolinic acid chromium(III) salt||C18H12CrN3O6||418.3||14639-25-9|
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