CAS 94-24-6 TOP Local Anesthetical Apis Tetracaine / Tetracaine HCl for Pain Killer

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Name: Tetracaine HCl CAS: 94-24-6
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Local Anesthetical Apis Tetracaine / Tetracaine HCl CAS 94-24-6 for Pain Killer


Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.


In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.


Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.


It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.


A systematic review investigated tetracaine for use in emergency departments, especially for intravenous cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first-attempt cannulations.


Product Name tetracaine hydrochloride
Alias Tetracaine HCl; 2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS Registry Number 136-47-0
Einecs No 205-248-5
Molecular Formula C15H25ClN2O2
Molecular Weight 300.8242
Flash Point 189.3°C
Appearance white powder
Boiliing Point 389.4°C at 760 mmHg
Vapor Pressure 2.87E-06mmHg at 25°C




Test Items Specification Test Results
Appearance Fine, white, crystalline, odorless powder confirm
Identification ABC in Pass confirm
Solubility Very soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene
USP Reference standards USP Tetracaine Hydrochloride RS.
USP Endotoxin RS.
Melting point 145~150 degree 146.0~147.5 degree
Chromatographic purity In Pass confirm
Related substance Not more than the reference solution 0.05% confirm
Heavy metals ≤10ppm confirm
PH 4.5-6.5 5.8
Residue on ignition ≤0.10% 0.05%
Loss on Drying ≤ 0.5% 0.19%
Assay 98.0 -101.0% 100.1%
Conclusion Confirms USP 32


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CAS 94-24-6 TOP Local Anesthetical Apis Tetracaine / Tetracaine HCl for Pain Killer 0


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