Pharmaceutical Intermediates 65277-42-1 Ketoconazole Hair Loss Treatment Powder

Pharmaceutical Intermediates 65277-42-1 Ketoconazole Hair Loss Treatment Powder

Ketoconazole (INN, USAN, BAN, JAN) is a synthetic imidazole antifungal drug used primarily to treat fungal infections. Ketoconazole is sold commercially as a tablet for oral administration (although this use has been discontinued in a number of countries).

And in a variety of formulations for topical administration, such as creams (used to treat tinea; cutaneous candidiasis, including candidal paronychia; and pityriasis versicolor) and shampoos (used primarily to treat dandruff-seborrhoeic dermatitis of the scalp).

Ketoconazole
CAS: 65277-42-1
EINECS: 265-667-4
MF: C26H28Cl2N4O4
MW: 531.43
Assay: 99.5%
standard:USP34
Package: 25 kilogram/cardboard drum
Appearance:White Powder
usage:Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic

Usual Adult Dose for Blastomycosis:

Initial dose: 200 mg orally once a day
If clinical responsiveness insufficient within expected time: Dose may be increased to 400 mg orally once a day.
Duration of therapy: 6 months (usual duration for systemic infection)

Usual Pediatric Dose for Blastomycosis:

2 years or older: 3.3 to 6.6 mg/kg orally once a day
Duration of therapy: 6 months (usual duration for systemic infection)

Comments:

-Ketoconazole should not be used unless the benefit outweighs the risks.
-Ketoconazole should not be used for fungal meningitis (penetrates poorly into CSF).
-The IDSA guidelines recommend amphotericin B and itraconazole as preferred therapies for blastomycosis and histoplasmosis.
Uses: For treatment of the following systemic fungal infections in patients who have failed or who are intolerant to other therapies: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, paracoccidioidomycosis

Administration advice:

-Take with a meal.

-Administer ketoconazole with an acidic drink (such as non-diet cola) if gastric acidity is reduced (e.g., in patients with achlorhydria due to certain diseases, in patients using acid secretion suppressors or acid-neutralizing therapy);

administer acid-neutralizing agents at least 1 hour before or 2 hours after ketoconazole.

Storage requirements:

Protect from moisture.

Medical uses:

Antifungal

Topical antifungal

Topically administered ketoconazole is usually prescribed for fungal infections of the skin and mucous membranes, such as athlete's foot, ringworm, candidiasis (yeast infection or thrush), jock itch, and tinea versicolor.

Topical ketoconazole is also used as a treatment for dandruff(seborrheic dermatitis of the scalp) and for seborrheic dermatitis on other areas of the body, perhaps acting in these conditions by suppressing levels of the fungus Malassezia furfur on the skin.

Systemic antifungal

Ketoconazole has activity against many kinds of fungi that may cause human disease, such asCandida, Histoplasma, Coccidioides, and Blastomyces (although it is not active againstAspergillus). First synthesized in 1977, ketoconazole was the first orally-active azoleantifungal medication.

However, ketoconazole has largely been replaced as a first-line systemic antifungal medication by other azole antifungal agents, such as, because of ketoconazole's greater toxicity, poorer absorption, and more limited spectrum of activity.

Ketoconazole is used orally in dosages of 200 to 400 mg per day in the treatment of superficial and deep fungal infections.

Our order process:

Our advantages:

1,Quality products with factory price;
2,We are manufacturer,products plenty in stock and orders can be delivered in the first time;
3,Rich experienced packing and delivery department,packages well disguised,fast and safe delivery,pass rate above 99%;
4,Express company:EMS,HKEMS,Fedex,TNT,UPS,DHL etc;
5,We have reship policy if parcel can't reach your hands due to custom;
6,24/7 online after-sales service.

FAQ:

Q how can I be sure the powder contains right substances?
S can offer you the cretificate of analysis of products and HPLC,Besides, After Receiving the goods, you can send it to detect, or buy a test kit steroid, detect it yourself.

Q What's the guarantees that you will send items after payment
S The feedback of customers:
Tracking Number :DHL3292172505
Yes,i have recieved it,really fast,good job,thanks.
-----Jean from France
We are regular company, we guarantee that after the receipt of your payment we will arrange the shipment within 24 hours , and provide the tracking number, you can keep track of it.so,don't hesitate to let me serve you.

Q What’s the MOQ?
S Generally speaking, the MOQ is 10 gram, but we also can provide you samples for quality inspection.

Q Do you charge for the samples?
S According to our company policy, we just charge the samples based on EXW price. And we will return the samples fee during the next order.

Q Can you packing according to customers' requirements ?
S Sure,we will adopt safe and discreet package.If you have a request for packing, please tell us,Any good ideas are welcomed.

Q Can you tell me your main customers?
S That's our customer’s privacy, we should protect their information.
At the same time, please rest assured that your information is also safe here.
 

Any needs, please contact me

Email: tonyraws810@gmail.com

Whatsapp: 86-15871352379

Wickr: tonyraws