|Place of Origin:||China|
|Minimum Order Quantity:||10grams|
|Packaging Details:||foil bag|
|Delivery Time:||Within 24 hours After Payment|
|Payment Terms:||T/T, Western Union, MoneyGram,Bitcoin|
|Supply Ability:||100kg per month|
|Product Name:||Coluracetam (MKC-231)||CAS NO:||135463-81-9|
|Molecular Formula:||C19H23N3O3||Appearance:||White Powder|
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|Product Name||Coluracetam (MKC-231)|
|Supply capacity||Mass in stock|
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|Packing||Well disguised package to pass the customs|
|Payment||Western Union, Money Gram, Bank Transfer|
|Leading time||Within 24 hours after payment.|
|Delivery time||3-7 work days|
|99% passing rate & 100% free resend policy|
Coluracetam (BCI-540; formerly MKC-231) is a nootropic agent of the racetam family. It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently[when?] out-licensing the drug for this purpose. [full citation needed] It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.
Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.
Coluracetam appears to interact with a process known as high affinity choline uptake (HACU for short), which is the rate-limiting step of drawing choline into a neuron for synthesis into the neurotransmitter acetylcholine. Increasing the HACU rate appears to increase the activity of cholinergic neurons, so it is a desired target for cognitive enhancement.
Interventions in rats (as there is no human evidence currently) support the usage of coluracetam at very low oral doses to preserve HACU that is otherwise impaired by the use of research drugs that are known to impair HACU. The limited evidence looking at the inherent effects of coluracetam on the HACU of normal neurons has failed to find any significant interaction.
Coluracetam has also been noted to associate with choline transporters physically, but it is not known exactly what it does once associated.
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4. The goods will reach you in 3~7 days.
WHY CHOOSE US?
1. High quality: Our factories are professional in raw powder production with experience over 10 years. Having good reputation all over the world, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
2. Competetive price: All powders are factory directly supplied, it's factory price and negotiable.
3. Fast and safe delivery: Your goods will be sent out within 24 hours after payment, tracking number available, customs pass rate ≥99%.
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