Injectable Contraceptive Prohormones Steroids Medroxyprogesterone 17- Acetate 71-58-9

Basic Information
Place of Origin: China
Brand Name: Desen Nutrition
Certification: ISO
Model Number: 71-58-9
Minimum Order Quantity: 10g,10vials, 50ml
Price: USD 1-2 grams
Packaging Details: Disguised , safe package, or as customer's demands
Delivery Time: 7 working days
Payment Terms: Bank Transfer, Western Union, MoneyGram, Bitcoin
Supply Ability: 50000kg/month
Email: Tonyraws810@gmail.com Whatsapp: 86-15871352379
Wickr: Tonyraws
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Product Name:Medroxyprogesterone 17-acetate
Synonyms:(6-alpha)-17-(acetyloxy)-6-methylpreg-4-ene-3,20-dione;17-(acetyloxy)-6-methyl-(6-alpha)-pregn-4-ene-20-dione;17-(acetyloxy)-6-methyl-20-dion(6alpha)-pregn-4-ene-;17-acetoxy-6-alpha-methylprogesterone;17-alpha-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate;17-alpha-hydroxy-6-alpha-methyl-progesteronacetate;17-alpha-hydroxy-6-alpha-methylprogesteroneacetate;17-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate
CAS:71-58-9
MF:C24H34O4
MW:386.52
EINECS:200-757-9
Product Categories:Antitumors for Research and Experimental Use;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;PROVERA;Hormone Drugs
Mol File: 71-58-9.mol


Drug abortion to patients with less pain, and safe and easy, is the early pregnancy pregnant patients with pregnancy termination of the usual method. However, the incidence of human chorionic gonadotropin decreased and the increase in estrogen was slow in the blood of patients after drug abortion, and the rate of shedding of chorionic villi was slowed down, resulting in bleeding and bleeding for a long time and affected the endometrial repair. Mifepristone combined with misoprostol is the most commonly used drug to terminate early pregnancy, but the bleeding after the abortion, bleeding longer. Therefore, it is necessary to seek a conservative treatment of vaginal bleeding after drug abortion. Some scholars have used Huoxue Huayu bleeding myogenic and other traditional Chinese medicine preparation treatment of vaginal bleeding after drug abortion, but the effect is not accurate. At present, the domestic vaginal bleeding after pregnancy for more than 14d patients, the use of estrogen progesterone continuous therapy, but the method of side effects, and the use of complex methods, patient compliance by a certain limit, the clinical feasibility of the general.
Angelica progesterone is a synthetic luteal progesterone, the raw material is white or almost white crystalline powder, easily soluble in chloroform, dissolved in acetone, slightly soluble in ethyl acetate, slightly soluble in ethanol ,Insoluble in water. Anguang progesterone can quickly repair the endometrium, the application of the drug after a period of withdrawal, there may be withdrawal bleeding, is due to the endometrial layer completely off, and a small amount of residual tissue within the uterus brought out, and thus To the role of drug curettage, can replace the Qing Gong surgery, auxiliary anti-infection treatment, can reduce the complications of drug abortion, and can quickly reduce bleeding, as soon as possible to stop bleeding, and clinical methods of operation is simple, patient compliance is good, easy to accept, with Good clinical feasibility; also can be widely used in the treatment of irregular menstruation, dysmenorrhea, injections can be used as long-acting contraceptives, large doses for the treatment of breast cancer; short-term (14d) oral medroxyprogesterone acetate 60mg / d) can effectively improve the male patients with chronic respiratory failure hypoxemia and carbon dioxide retention, and daily meal service, medication convenience; short-term medication did not appear blood lipids and blood pressure, has a certain clinical value; Ketones can also be used to treat female hirsutism, intramuscular injection, each 100mg, 2 times a month.

 

Clinical Application:


1. Gynecological applications
1) for long-acting contraceptives: This product can inhibit ovarian ovulation, it is often used as long-acting contraceptives.
2) treatment of dysmenorrhea, irregular menstruation, functional amenorrhea, functional uterine bleeding, threatened abortion or habitual abortion.
3) for medical abortion: the current mifepristone compatibility misoprostol termination of early pregnancy in clinical widely used, complete abortion rate of up to 90% or more. There was still vaginal bleeding at 14 days after drug abortion, and there was a strong echo group or mixed light group (less than 32cm2) in the cavity of B, and the patients with negative human chorionic gonadotropin (HCG) and fear of clearing the uterus , The use of analgin progesterone drug curettage compatibility five plus biochemical capsule for clinical treatment, the results are satisfactory, to avoid the Qing Gong surgery damage, reduce the incidence of complications, but also lifted some women due to fear of Qing surgery caused by psychological fear and Spiritual pain.
4) treatment of endometriosis or endometriosis caused by pain.
5) treatment of chocolate cysts: chocolate cyst patients in the first 5 days of menstrual first intramuscular injection of medroxyprogesterone acetate 150mg, then every interval (90 ± 7) d injection 1, half a year, a course of treatment. , After treatment, the diameter of patients with cysts greatly reduced; patients before the symptoms of dysmenorrhea basically disappeared or alleviate the clinical effect is obvious and safe, inexpensive, easy to use.
6) postmenopausal women use: for menopausal vasomotor symptoms, each 150mg, every 3 months deep intramuscular injection 1 times. This product alone or in combination with estrogen for postmenopausal women, can reduce their cysteine ​​levels, regardless of the use of progesterone dose, 3 years after the cysteine ​​metabolism has no effect. More than 50 years of postmenopausal women with long-term use of medroxyprogesterone acetate, can improve its follicle stimulating hormone (FSH) levels.

 

2. Anti-tumor effect
This product is commonly used in palliative or adjunctive treatment of non-surgical, recurrent or metastatic hormone-dependent tumors such as breast cancer, endometrial cancer, kidney cancer and prostate cancer. Studies have shown that long-term oral administration of progesterone in the treatment of endometrial cancer, can activate the epidermal growth factor receptor, which play a therapeutic role. Oral administration of 100mg each time,

3 times a day, or every 500mg, 1-2 times a day, at least 1 month, effective long-term use (as intramuscular injection of maintenance). The dose of the dispersible tablet is 200-400 mg per day. For prostate cancer, oral, each 500mg, 1-2 times a day, at least 1 month, effective long-term use. For kidney cancer, oral, the initial dose of 0.4-1g each time, once a week, if weeks or months to improve the condition and stability, you can use maintenance dose, each 0.4g, 1 month The

 

3. Antitumor synergies
1) on bone marrow protection of tumor chemotherapy: Ampelopsin can inhibit bone marrow stem cell mitotic activity and differentiation, so that cells in a quiescent, so that no significant reduction in white blood cells during chemotherapy, chemotherapy tolerance improved to ensure that chemotherapy Done successfully. Commonly used dispersible tablets, daily 0.5-1g, 1 week before chemotherapy with 1 chemotherapy to 1 week after treatment.
2) to reduce the chemotherapy-induced gastrointestinal reactions: chemotherapy combined with analgesterone, can be advanced gastric cancer patients with appetite, weight and general status score significantly improved compared with chemotherapy alone, and gastrointestinal reactions and the incidence of myelosuppression and Less severe, and this short course of intermittent medication no obvious liver, kidney damage and deep vein thrombosis.
3) on the growth of human colon cancer LS174T cells in vivo inhibition: after administration of progesterone, the human colon cancer transplanted tumor LS174T cell growth has a significant inhibitory effect and induced apoptosis, the mechanism may be related to medroxyprogesterone LS174T cells are involved in G1 phase and upregulation of Fas and FasL expression on cell surface.
4) Enhance the antitumor effect of cisplatin on human ovarian cancer resistant cells: This product has obvious reversal effect on human ovarian cancer resistant cells in cisplatin in vivo, and its mechanism may be related to its ability to induce apoptosis and increase The accumulation of cisplatin in cells is relevant.
5) inhibition of pelvic pathology angiogenesis: the product of ovarian cancer pelvic pathogenesis of angiogenesis significantly inhibited; combined chemotherapy can extend the survival time of ovarian cancer patients; internal iliac arterial angiography showed pelvic pathological blood vessels, can be used as evaluation of treatment and prognosis Of the indicators; continuous taking 12 months of analgin

 

 

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FAQ:


1)Location & Working Hours
We are an International source locate in China.
I will answer emails from Monday to Saturday, 8:30 am to 18:00 pm (GMT+8)


2)How long does it takes to get back a response from you?
You should receive a response in less than 24 hours.


3)How do I make an order?
When you choosed the products, please email me, and I will quote for you, if you are satisfied with it, then pay for it, the parcle will be sent for you as soon as possible.


4)How to track my order?
After I ship your order and have the tracking number, you will receive an email notification. All tracking numbers I provide can be tracked at http://www.17track.net/en. Or you can ask me for helping you track it too.


5)How long does the whole process take, from making an order till receiving the package?
The package will be prepared within 1 working day after payment received and be sent out within 72 hours.
The delivery time depends on the shipping situation and customs.
The shipping time will not more than 15 working days at most.


6)How about the shipping cost?
The shipping cost is for the whole order. No matter how many different items and quantity in one orders. The shipping cost will be charged only once.


7)Is there a minimum order?
For raw powder: MOQ is 10g
For oil liquid: MOQ is 50ml
For peptide vial: MOQ is 10 vials


8)Reship Policy
To U.S. We reship for free twice if your package gets seized.
To other countries we reship for free once if your package gets seized.
If you choose not to reship or the resent package failed to go through again, no refund will be made.


9)Payment Ways
We accept Bank Transfer(T/T ), Western Union, Moneygram, Bitcoin.
*** The Bitboin is a little special for us, our Bitcoin account is always changing, once I gave you the account number, please pay for it at once.


10)Refund policy
Our company has a 2 reship policy all foreign countries in case of a seizure.
**We are not responsible if you throw away your products because you cannot find them in our disguised package. If you cannot find your products please email me and I will tell you where to find them.

 

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