Dutasteride for Benign Prostatic Hyperplasia and Androgenetic Alopecia

Basic Information
Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS 164656-23-9
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 kg / month
MW: 528.5297 MF: C27H30F6N2O2
Appearance: White Crystalline Powder Half Life: 5 Weeks
CAS: 164656-23-9 Shipment: FedEx, TNT, EMS, DHL.UPS,EUB
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Dutasteride for Benign Prostatic Hyperplasia and Androgenetic Alopecia

 

CAS number164656-23-9

WeightAverage: 528.5297
Monoisotopic: 528.221147444

Chemical Formula:C27H30F6N2O2

Half life:5 weeks

Chemical Structure:

 

Dutasteride for  Benign Prostatic Hyperplasia and Androgenetic Alopecia 0

 

Dutasteride, sold under the brand name Avodart among others, is a medication used to treat benign prostatic hyperplasia and androgenetic alopecia (pattern hair loss).

 

It was developed by GlaxoSmithKline and is a 5α-reductase inhibitor which prevents the conversion of the androgen sex hormone testosterone into the more potent dihydrotestosterone (DHT). The drug has been licensed for the treatment of androgenetic alopecia in South Korea since 2009, but has not been approved for this indication in the United States, though it is commonly used off-label.

 

Medical uses

Prostate enlargement

 

Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate".


Prostate cancer

 

In those who are being regularly screened, 5α-reductase inhibitors such as finasteride and dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.


Pattern hair loss

 

Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea at a dosage of 0.5 mg per day. It has been found in several studies to improve hair growth in men more rapidly and to a greater extent than 2.5 mg/day finasteride.Dutasteride has also been used off-label in the treatment of female pattern hair loss.

 

Before using dutasteride:

 

Some medical conditions may interact with dutasteride. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

 

Some MEDICINES MAY INTERACT with dutasteride. Tell your health care provider if you are taking any other medicines, especially any of the following:

 

This may not be a complete list of all interactions that may occur. Ask your health care provider if dutasteride may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

 

Predicted Properties

 

Water Solubility 0.000908 mg/mL ALOGPS
logP 5.45 ALOGPS
logP 5.79 ChemAxon
logS -5.8 ALOGPS
pKa (Strongest Acidic) 12.56 ChemAxon
pKa (Strongest Basic) 2.17 ChemAxon
Physiological Charge 0 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 2 ChemAxon
Polar Surface Area 58.2 Å2 ChemAxon
Rotatable Bond Count 4 ChemAxon
Refractivity 127.9 m3·mol-1 ChemAxon
Polarizability 50.13 Å3 ChemAxon
Number of Rings 5 ChemAxon
Bioavailability 0 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter Yes ChemAxon
Veber's Rule Yes ChemAxon
MDDR-like Rule Yes ChemAxon

 

 

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