Dutasteride for Benign Prostatic Hyperplasia and Androgenetic Alopecia

Dutasteride for Benign Prostatic Hyperplasia and Androgenetic Alopecia

CAS number164656-23-9

WeightAverage: 528.5297
Monoisotopic: 528.221147444

Chemical Formula:C₂₇H₃₀F₆N₂O₂

Half life:5 weeks

Chemical Structure:

Dutasteride, sold under the brand name Avodart among others, is a medication used to treat benign prostatic hyperplasia and androgenetic alopecia (pattern hair loss).

It was developed by GlaxoSmithKline and is a 5α-reductase inhibitor which prevents the conversion of the androgen sex hormone testosterone into the more potent dihydrotestosterone (DHT). The drug has been licensed for the treatment of androgenetic alopecia in South Korea since 2009, but has not been approved for this indication in the United States, though it is commonly used off-label.

Medical uses

Prostate enlargement

Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate".

Prostate cancer

In those who are being regularly screened, 5α-reductase inhibitors such as finasteride and dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.

Pattern hair loss

Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea at a dosage of 0.5 mg per day. It has been found in several studies to improve hair growth in men more rapidly and to a greater extent than 2.5 mg/day finasteride.Dutasteride has also been used off-label in the treatment of female pattern hair loss.

Before using dutasteride:

Some medical conditions may interact with dutasteride. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have heart failure, urinary tract problems, or problems urinating
• if you have a history of abnormal liver function tests, prostate cancer, increased serum prostate-specific antigen (PSA) levels, or liver problems

Some MEDICINES MAY INTERACT with dutasteride. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Ritonavir because it may increase the risk of dutasteride's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if dutasteride may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Predicted Properties

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