Finasteride for Benign Prostatic Hyperplasia (BPH) and Male Pattern Baldness

Finasteride for Benign Prostatic Hyperplasia (BPH) and Male Pattern Baldness

Alias: Proscar;Propecia
CAS NO.: 98319-26-7
Molecular Formula: C20H24O2
Molecular weight: 372.54
Assay: 99%min

Chemical Structure:

Appearance:white crystalline solid
Usage: for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB)

Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). It is a type II and type III 5α-reductase inhibitor; 5α-reductase, an enzyme, converts testosterone to dihydrotestosterone (DHT).

Medical uses

Benign prostatic hyperplasia

Physicians use finasteride for the treatment of BPH, informally known as an enlarged prostate. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow. It provides less symptomatic relief than alpha-1 blockers such as tamsulosin and symptomatic relief is slower in onset (six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment).

Symptomatic benefits are mainly seen in those with prostate volume > 40 cm3. In long-term studies finasteride but not alpha-1 inhibitors reduce the risk of acute urinary retention (−57% at 4 years) and the need for surgery (−54% at 4 years). If the drug is discontinued, any therapeutic benefits reverse within about 6–8 months.

Male pattern baldness

Finasteride is used to treat male pattern hair loss (androgenetic alopecia) in men only.Treatment slows further hair loss and provides about 30% improvement in hair loss after six months of treatment, with effectiveness only persisting as long as the drug is taken.

Off-label uses

Finasteride is sometimes used in hormone replacement therapy for transgender women in combination with a form of estrogen due to its antiandrogen properties. However, little clinical research of finasteride use for this purpose has been conducted and evidence of efficacy is limited.

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