17-Methyltestosterone Oral Anabolic Steroids for Sexual Development CAS 58-18-4

17-Methyltestosterone Oral Anabolic Steroids for Sexual Development CAS 58-18-4

Metandren, Android, Hormale, Methyltestosteronmalestron, Methyltestosteronum
CAS: 58-18-4
EINECS: 200-366-3
Molecular Fomula: C20H30O2
Molecular Weight: 302.45
Assay: 99% min.

Chemical Structure:

MP: 161-166 degree Celsius
Refractive index: +69-+75° .

Character: White crystalline powder. Odorless, tasteless, hygroscopic, light case of deterioration. Ethanol solution at 240nm wavelength of maximum absorption.

Methyltestosterone (brand names Android, Androral, Metandren, Oraviron, Testred, Virilon),also known as 17α-methyltestosterone, is a 17α-alkylated androgenic-anabolic steroid (AAS) used to treat males with a testosterone deficiency. It bears close structural similarity to testosterone, but has a methyl group at C17α in order to increase oral bioavailability. Due to aromatization to the metabolization-resistant estrogen 17α-methylestradiol, methyltestosterone has relatively high estrogenicity and hence side effects such as gynecomastia

Uses:

This medication is used in men who do not make enough of a natural substance called testosterone. In males, testosterone is responsible for many normal functions, including growth and development of the genitals, muscles, and bones. It also helps cause normal sexual development (puberty) in boys. Methyltestosterone is similar to the natural testosterone produced by your body. It belongs to a class of drugs known as androgens. It works by affecting many body systems so that the body can develop and function normally.Methyltestosterone may also be used in certain adolescent boys to cause puberty in those with delayed puberty.

Mechanism of action

The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase.

DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

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