DHEA / Dehydroepiandrosterone Oral Anabolic Steroids for Anti-Aging CAS 53-43-0

Basic Information
Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS 53-43-0
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 kg / month
MW: 288.424 MF: C19H28O2
Appearance: White Crystalline Powder Melting Point: 148.5 °C (299.3 °F)
Synonyms: (3β)-3-Hydroxyandrost-5-en-17-one Shipment: FedEx, TNT, EMS, DHL.UPS,EUB
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DHEA / Dehydroepiandrosterone Oral Anabolic Steroids for Anti-Aging CAS 53-43-0

 

Dehydroepiandrosterone /dehydroepiandrostenedione (DHEA, more correctly didehydroepiandrosterone), also known as androstenolone as well as 3β-hydroxyandrost-5-en-17-one or 5-androsten-3β-ol-17-one, is an endogenous steroid hormone. In its pharmaceutical drug form it is called prasterone (INN).

 

It is the most abundant circulating steroid hormone in humans,in whom it is produced in the adrenal glands, the gonads, and the brain, where it functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids. However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors,and acting as a neurosteroid.

 

Medical aspects

 

In women with adrenal insufficiency and the healthy elderly there is insufficient evidence to support the use of DHEA.

 

Cancer

 

There is no evidence DHEA is of benefit in treating or preventing cancer.Although DHEA is postulated as an inhibitor towards glucose-6-phosphate dehydrogenase (G6PD) and suppresses leukemia cell proliferation in vitro, DHEA may enhance G6PD mRNA expression, confounding its inhibitory effects.

 

Strength

 

Evidence is inconclusive in regards to the effect of DHEA on strength in the elderly.

In middle-aged men, no statistically significant effect of DHEA supplementation on lean body mass, strength, or testosterone levels was found in a randomized placebo-controlled trial.

 

Memory

 

DHEA supplementation has not been found to be useful for memory function in normal middle aged or older adults. It has been studied as a treatment for Alzheimer's disease, but there is no evidence that it is effective.

 

Cardiovascular disease

 

A review in 2003 found the then-extant evidence sufficient to suggest that low serum levels of DHEAS may be associated with coronary heart disease in men, but insufficient to determine whether DHEA supplementation would have any cardiovascular benefit.

 

Lupus

 

There is some evidence of short-term benefit in those with systemic lupus erythematosus but little evidence of long-term benefit or safety.

 

Body composition

 

A meta-analysis of intervention studies shows that DHEA supplementation in elderly men can induce a small but significant positive effect on body composition that is strictly dependent on DHEA conversion into its bioactive metabolites such as androgens or estrogens.

 

Property Value Source
melting point 140-141 °C PhysProp
water solubility 63.5 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP 3.23 HANSCH,C ET AL. (1995)
Water Solubility 0.0438 mg/mL ALOGPS
logP 3.53 ALOGPS
logP 3.36 ChemAxon
logS -3.8 ALOGPS
pKa (Strongest Acidic) 18.2 ChemAxon
pKa (Strongest Basic) -1.4 ChemAxon
Physiological Charge 0 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 1 ChemAxon
Polar Surface Area 37.3 Å2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 84.66 m3·mol-1 ChemAxon
Polarizability 34.09 Å3 ChemAxon
Number of Rings 4 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter Yes ChemAxon
Veber's Rule Yes ChemAxon
MDDR-like Rule Yes ChemAxon

DHEA / Dehydroepiandrosterone Oral Anabolic Steroids for Anti-Aging CAS 53-43-0 0

 

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