Benzocaine Raw Powders for Local Anesthetic CAS 94-09-7

Basic Information
Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS 94-09-7
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 kg / month
Melting Point: 92 °C Water Solubility: 1310 Mg/L (at 30 °C)
Appearance: White Crystalline Powder Boiling Point: 310 °C
Usage: Local Anesthetic Shipment:: FedEx, TNT, EMS, DHL.UPS,EUB
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Benzocaine Raw Steroid Powders for Local Anesthetic CAS 94-09-7

 

Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.

 

Chemical properties

 

Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform and ethyl ether. The melting point of benzocaine is 88–90 °C, and the boiling point is about 310 °C.The density of benzocaine is 1.17 g/cm3.

 

History

 

Benzocaine was first synthesized in 1890 by the German chemist Eduard Ritsert (1859–1946),in the town of Eberbach and introduced to the market in 1902 under the name "Anästhesin".

 

Mechanism of action

 

Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential.

 

Uses

 

Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for:

 

Other uses

 

Benzocaine is used as a key ingredient in numerous pharmaceuticals:

 

Experimental Properties

 

Property Value Source
melting point 92 °C PhysProp
boiling point 310 °C PhysProp
water solubility 1310 mg/L (at 30 °C) YALKOWSKY,SH & HE,Y (2003)
logP 1.86 HANSCH,C ET AL. (1995)
pKa 2.51 (at 25 °C) PERRIN,DD (1965)

 

Predicted Properties

 

Property Value Source
Water Solubility 2.85 mg/mL ALOGPS
logP 2.2 ALOGPS
logP 1.5 ChemAxon
logS -1.8 ALOGPS
pKa (Strongest Basic) 2.78 ChemAxon
Physiological Charge 0 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 1 ChemAxon
Polar Surface Area 52.32 Å2 ChemAxon
Rotatable Bond Count 3 ChemAxon
Refractivity 47.53 m3·mol-1 ChemAxon
Polarizability 17.46 Å3 ChemAxon
Number of Rings 1 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter Yes ChemAxon
Veber's Rule Yes ChemAxon
MDDR-like Rule Yes ChemAxon

 

 

Benzocaine Raw Powders for Local Anesthetic CAS 94-09-7 0

 

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