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|Appearance:||Colorless Liquid||Density:||1.118 G/cm3|
|Flash Point:||158 °C (316 °F) (closed Cup)||Alias:||BB|
|Melting Point:||18 °C (64 °F; 291 K)||Boiling Point:||323 °C (613 °F; 596 K)|
raw pharmaceutical materials,
raw materials for pharmaceutical products
BB / Benzyl Benzoate Pharmaceutical Intermediates CAS 120-51-4
Benzyl benzoate is an organic compound with the formula C6H5CH2O2CC6H5. It is the ester of benzyl alcohol and benzoic acid. It forms either a viscous liquid or solid flakes and has a weak, sweet-balsamic odor. It occurs in a number of blossoms (e. g. tuberose, hyacinth) and is a component of Balsam of Peru and Tolu balsam.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Benzyl benzoate is used as a topical acaricide, scabicide, and pediculicide in veterinary hospitals. It is also a repellent for chiggers, ticks, and mosquitoes. It is an effective and inexpensive topical treatment for human scabies. It has vasodilating and spasmolytic effects and is present in many asthma and whooping cough drugs.
Benzyl benzoate is also used as a dye carrier, solvent for cellulose derivatives, plasticizer, and fixative in the perfume industry.
Benzyl benzoate is an excipient in some testosterone-replacement medications (like Nebido) for treating hypogonadism.
Benzyl benzoate has low acute toxicity in laboratory animals. It is rapidly hydrolyzed to benzoic acid and benzyl alcohol. Benzyl alcohol is subsequently metabolized to benzoic acid. The conjugates of benzoic acid are rapidly eliminated in urine. When given in large doses to laboratory animals, benzyl benzoate can cause hyperexcitation, loss of coordination, ataxia, convulsions, and respiratory paralysis.
Benzyl benzoate can be a skin irritant when used as a topical scabicide.Overdose can result in blistering and hives or a rash can occur as an allergic reaction.
As an excipient in some testosterone-replacement injectable medications, benzyl benzoate has been reported as a cause of anaphylaxis in a case in Australia. Bayer includes this report in information for health professionals and recommends that physicians "should be aware of the potential for serious allergic reactions" to preparations of this type.
|Molar mass||212.25 g·mol−1|
|Melting point||18 °C (64 °F; 291 K)|
|Boiling point||323 °C (613 °F; 596 K)|
Solubility in water
|Solubility||miscible in alcohol, chloroform, ether, oils
soluble in acetone, benzene
insoluble in glycerol
Refractive index (nD)
|1.5681 (21 °C)|
|Flash point||158 °C (316 °F) (closed cup)|
|481 °C (898 °F; 754 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|1700 mg/kg (rat, oral)|
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