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Misoprostol, sold under the brandname Cytotec among others, is a medication used to start labor, cause an abortion, prevent and treat stomach ulcers, and treat postpartum bleeding due to poor contraction of the uterus.
Oral Pharmaceutical Misoprostol CAS 59122-46-2 For stomach Ulcer prevention
Misoprostol Quick Detail:
For abortions Misoprostol is often used with mifepristone or methotrexate.
By itself effectiveness for this purpose is between 66% and 90%.Misoprostol is taken either by mouth, under the tongue, or placed in the vagina.
|Boiling point||465.894°C at 760 mmHg|
|Appearance||White crystalline powder|
Misoprostol Medical uses:
Misoprostol is used for the prevention of NSAID-induced gastric ulcers. Misoprostol acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications.
Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration.
Misoprostol is commonly used for labor induction. Misoprostol causes uterine contractions and the ripening (effacement or thinning) of the cervix. Misoprostol can be significantly less expensive than the other commonly used ripening agent, dinoprostone.
Oxytocin has long been used as the standard agent for labor induction, but does not work well when the cervix is not yet ripe. Misoprostol also may be used in conjunction with oxytocin.
Misoprostol is used either alone or in conjunction with an other medication (mifepristone or methotrexate) for medical abortions as an alternative to surgical abortion. Medical abortion has the advantage of being less invasive, and more autonomous, self-directed, and discreet. It is preferable to users because it feels more "natural," as the drugs induce a miscarriage. Misoprostol is also more easily accessible in places where abortion is illegal.The World Health Organization provides clear guidelines on the use, benefits and risks of misoprostol for abortions.
Misoprostol is most effective when it is used with methotrexate or mifepristone (RU-486). Misoprostol alone is less effective (typically 88% up to eight-weeks gestation).
Misoprostol is sometimes used to treat early fetal death in the absence of spontaneous miscarriage, but further research is needed to establish a safe, effective protocol.
Misoprostol is also used to prevent and treat post-partum bleeding. Orally administered misoprostol was marginally less effective than oxytocin.
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|Medroxyprogesterone Acetate||CAS: 71-58-9|
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