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Pregabalin works by reducing the abnormal electrical activity in the brain. It is taken alongside other medicines for epilepsy. Pregabalin can also be helpful in treating the symptoms of generalised anxiety disorder (GAD), particularly if other medicines which are more often prescribed for people with this condition are not suitable. GAD is a long-term condition where anxiety is a major symptom.
Pregabalin Pharmaceutical Intermediates Lyrica Antiepileptic Treatment Drugs CAS 148553-50-8
Quick View:
Name: Pregabalin
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Assay: 99%
Appearance: White Crystal Powder
Specification: CP
Package: 25kg/drum
Use: New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures adjuvant treatment.
Descriptions:
Pregabalin belongs to a group of medicines known as anti-epileptic medicines, although it is prescribed for the treatment of several different conditions. You may have been prescribed it for the treatment of partial seizures, which is a type of epilepsy. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. With a partial seizure, the burst of electrical activity stays in one part of the brain. Therefore, you tend to have localised or 'focal' symptoms. Pregabalin is also prescribed to treat certain types of long-lasting pain caused by damage to nerves. This type of pain, called neuropathic pain, can be caused by a number of different conditions, including diabetes (where it is called diabetic neuropathy) and shingles(where it is called postherpetic neuralgia).
COA:
ITEMS |
STANDARDS |
RESULTS |
Appearance |
A white to off white powder |
White powder |
Identification |
A. Meets the requirement |
Complies |
B. IR: similar to Reference Substance |
Complies |
|
Loss on drying |
≤0.5% |
0.21% |
Specific Rotation |
+10.0°~+13.0° |
+10.8° |
Related Substances |
Any single impurity ≤0.1% Total impurity ≤0.8% |
0.05% 0.10% |
Purity By HPLC R-isomer |
≤0.15% |
0.10 |
Residue on ignition |
≤0.1% |
0.05% |
Residual solvents |
Isopropyl alcohol ≤5000ppm Ethyl Acetate ≤5000ppm |
150ppm 250ppm |
Heavy metals |
≤10ppm |
Complies |
Chlorides |
≤0.05% |
Complies |
Assay |
98%~102.0% |
99.8% |
Conclusion |
Analyse according to Factory Standard , Conform |
Applications:
Pregabalin is a medication used to in the treatment of epilepsy, neuropathic pain, fibromyalgia and generalized anxiety disorder. Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.
Pregabalin is a structural analogue of the neurotransmitter GABA, consequently it belongs to the acid analogue class of antiepileptic drugs. Its a ion channel modulator that has analgesic, anticonvulsant, sedative, and anxiolytic properties. Pregabalin is a potent gabapentinoid and close analogue of GABOB, baclofen, and phenibut.
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