4-Androstenedione Raw Steroid Powders for Treatment of Anorchia Replacement Therapy

Basic Information
Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS 63-05-8
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 kg / month
MW: 286.4 MF: C19H26O2
Appearance: White Crystalline Powder Water Solubility: 57.8 Mg/L (at 25 °C)
Alias: 4-Androstene-3,17-dione Shipment:: FedEx, TNT, EMS, DHL.UPS,EUB
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4-Androstenedione Raw Steroid Powders for Treatment of Anorchia Replacement Therapy

 

Systematic (IUPAC) name:

4-Androstene-3,17-dione
CAS Number :63-05-8
Formula :C19H26O2
Molar mass :286.4 g/mol
Chemical Structure:
4-Androstenedione Raw Steroid Powders for Treatment of Anorchia Replacement Therapy 0
 

Δ4-Androstenedione (abbreviated as Δ4-dione), commonly referred to simply as androstenedione, and also known as androst-4-ene-3,17-dione or 17-ketotestosterone, is an endogenous androgen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA). In turn, Δ4-dione is also a precursor of dihydrotestosterone (DHT), estrogens such as estradiol and estrone, and the neurosteroid 3α-androstanediol.

 

Biological role

 

Precursor/metabolic intermediate

 

Δ4-Dione is converted to either testosterone or estrogen.

In males, conversion of Δ4-dione to testosterone requires the enzyme 17β-hydroxysteroid dehydrogenase.

In females, Δ4-dione is released into the blood by theca cells. Conversion of Δ4-dione to estrogen (e.g., estrone and estradiol) requires the enzyme aromatase. Δ4-Dione is a substrate for estrogen production in granulosa cells which produce aromatase. Thus, theca cells and granulosa cells work together to form estrogens.

 

Levels are normally 30-200 ng/dL (1.0-7.0 nmol/l) in females and 40-150 ng/dL (1.4-5.2 nmol/l) in males.

Androstanedione is a 5α-reduced metabolite of 4-androstenedione which serves as an intermediate in the biosynthesis of the androgen and neurosteroid androsterone.

 

Estrogen

 

Δ4-Dione has been found to possess estrogenic actions, similarly to other DHEA metabolites. However, in contrast to 5-androstenediol, its affinity for the estrogen receptors is very low, with less than 0.01% of the affinity of estradiol for both the ERα and ERβ.

 

Experimental Properties

 

Property Value Source
melting point 158 °C PhysProp
water solubility 57.8 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP 2.75 HANSCH,C ET AL. (1995)
logS -3.69 ADME Research, USCD

 

 Predicted Properties

 

Property Value Source
Water Solubility 0.027 mg/mL ALOGPS
logP 2.93 ALOGPS
logP 3.93 ChemAxon
logS -4 ALOGPS
pKa (Strongest Acidic) 19.03 ChemAxon
pKa (Strongest Basic) -4.8 ChemAxon
Physiological Charge 0 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 34.14 Å2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 83.61 m3·mol-1 ChemAxon
Polarizability 33.2 Å3 ChemAxon
Number of Rings 4 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter Yes ChemAxon
Veber's Rule Yes ChemAxon
MDDR-like Rule Yes ChemAxon

 

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