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Olaparib / Lynparza PARP Inhibitor Most Effective Anticancer Drug

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Olaparib / Lynparza PARP Inhibitor Most Effective Anticancer Drug

Olaparib / Lynparza PARP Inhibitor Most Effective Anticancer Drug
Olaparib / Lynparza PARP Inhibitor Most Effective Anticancer Drug Olaparib / Lynparza PARP Inhibitor Most Effective Anticancer Drug

Large Image :  Olaparib / Lynparza PARP Inhibitor Most Effective Anticancer Drug

Product Details:
Place of Origin: China
Brand Name: ChineseHormone
Certification: ISO9001,SGS,UKAS
Model Number: CAS 763113-22-0
Payment & Shipping Terms:
Minimum Order Quantity: Free samples Available
Price: negotiated
Packaging Details: as your required
Delivery Time: 3-7 working days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000kg / month
Detailed Product Description
MF: C24H23FN4O3 MW: 435.08
Alias: Lynparza Protein Binding: Approximately 82%.
Appearance: White Powder Biological Half-Life: 11.9 Hours, Standard Deviation 4.8 Hours.
Email: Tonyraws810@gmail.com Whatsapp: 86-15871352379
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Olaparib / Lynparza PARP Inhibitor Most Effective Anticancer Drug

 

Trade names: Lynparza

Formula C24H23FN4O3

Molar mass 435.08 g/mol

CAS Number 763113-22-0

Protein Binding:Approximately 82%.

Biological Half-Life:11.9 hours, standard deviation 4.8 hours.

 

Description:

 

Lynparza is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. PARP enzymes are involved in normal cellular homeostasis, such as DNA transcription, cell cycle regulation, and DNA repair. Olaparib has been shown to inhibit growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer both as monotherapy or following platinum-based chemotherapy.

 

Increased cytotoxicity and anti-tumor activity following treatment with olaparib were noted in cell lines and mouse tumor models with deficiencies in BRCA. In vitro studies have shown that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complex, resulting in disruption of cellular homeostasis and cell death.

 

Olaparib is used for:

 

Treating advanced ovarian cancer in certain patients. It may also be used for other conditions as determined by your doctor.

Olaparib is a PARP enzyme inhibitor. It works by killing certain cancer cells.

Do NOT use olaparib if:

 

  • you are allergic to any ingredient in olaparib

  • you still have blood problems caused by previous chemotherapy treatments

  • you are taking carbamazepine, phenytoin, rifampin, or St. John's wort

 

Contact your doctor or health care provider right away if any of these apply to you.

 

How to use olaparib:

 

Use olaparib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

 

  • Olaparib comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get olaparib refilled.

  • Swallow olaparib whole. Do not chew, dissolve, or open the capsule before swallowing.

  • Do not take the capsule if it is deformed or leaking.

  • Avoid food or drink containing grapefruit or Seville oranges while you are taking olaparib.

  • Continue to take olaparib even if you feel well. Do not miss any doses.

  • If you miss a dose of olaparib, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

 

Ask your health care provider any questions you may have about how to use olaparib.

 

 

Olaparib / Lynparza PARP Inhibitor Most Effective Anticancer Drug 0

 

Computed Properties

 

Molecular Weight 434.471 g/mol
XLogP3 1.9
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 4
Exact Mass 434.175 g/mol
Monoisotopic Mass 434.175 g/mol
Topological Polar Surface Area 82.1 A^2
Heavy Atom Count 32
Formal Charge 0
Complexity 790
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1

 

 

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