Indapamide Pharmaceutical Intermediates Thiazide - like Diuretic Drug CAS 26807-65-8

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Place of Origin: China
Brand Name: ChineseHormone
Certification: GMP, ISO 9001, USP
Model Number: CAS 26807-65-8
Minimum Order Quantity: Free samples Available
Price: negotiated
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Delivery Time: 3-7 working days
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Supply Ability: 500-1000 kg / month
MW: 365.835 MF: C16H16ClN3O3S
Appearance: White Crystalline Powder Protein Binding: 71–79%
Biological Half-life: 14–18 Hours Shipment:: FedEx, TNT, EMS, DHL.UPS,EUB
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Indapamide Pharmaceutical Intermediates Thiazide-like Diuretic Drug 

 

Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment ofhypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

 

Form and composition

 

Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets.It is now also available in SR (sustained release) form.

 

Indications

 

Hypertension and edema due to congestive heart failure. Indapamide has been proven in the HYVET trial to reduce stroke and all cause mortality when given with or without  to people over the age of 80 for the treatment of hypertension.

 

Other uses for this medicine

 

Indapamide also is used to treat swelling and fluid retention caused by various medical conditions other than heart disease. Talk to your doctor about the possible risks of using this medicine for your condition.

 

Dosage and administration

 

The adult dosage is 1.25 to 5 mg, orally and once daily, usually in the morning.

 

Contraindications

 

Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe kidney failure, hepatic encephalopathy or severe liver failure, and a low blood potassium level.

There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding.

 

Interactions

 

Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave-burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).

 

Precautions

 

Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.

Adverse effects

Commonly reported adverse events are hypokalemia (low potassium levels), fatigue, orthostatic hypotension (blood pressure decrease on standing up) and allergic manifestations.

 

Overdosage

 

Symptoms of overdosage would be those associated with a diuretic effect, i.e. electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting electrolyte abnormalities.

 

Do NOT use indapamide if

 

 

 
Indapamide
Indapamide.svg
Systematic (IUPAC) name 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoyl-benzamide
Protein binding 71–79%
Biological half-life 14–18 hours
CAS Number 26807-65-8
Formula C16H16ClN3O3S
Molar mass 365.835 g/mol

 

 

Indapamide Pharmaceutical Intermediates Thiazide - like Diuretic Drug CAS  26807-65-8 1

 

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