Indapamide Pharmaceutical Intermediates Thiazide - like Diuretic Drug CAS 26807-65-8

Indapamide Pharmaceutical Intermediates Thiazide-like Diuretic Drug 

Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment ofhypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

Form and composition

Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets.It is now also available in SR (sustained release) form.

Indications

Hypertension and edema due to congestive heart failure. Indapamide has been proven in the HYVET trial to reduce stroke and all cause mortality when given with or without  to people over the age of 80 for the treatment of hypertension.

Dosage and administration

The adult dosage is 1.25 to 5 mg, orally and once daily, usually in the morning.

Contraindications

Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe kidney failure, hepatic encephalopathy or severe liver failure, and a low blood potassium level.

There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding.

Interactions

Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave-burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).

Precautions

Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.

Adverse effects

Commonly reported adverse events are hypokalemia (low potassium levels), fatigue, orthostatic hypotension (blood pressure decrease on standing up) and allergic manifestations.

Overdosage

Symptoms of overdosage would be those associated with a diuretic effect, i.e. electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting electrolyte abnormalities.

Do NOT use indapamide if

• you are allergic to any ingredient in indapamide or to a sulfonamide medicine (eg, sulfamethoxazole)

• you are unable to urinate

• you are taking ketanserin

Indapamide
Systematic (IUPAC) name	4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoyl-benzamide
Protein binding	71–79%
Biological half-life	14–18 hours
CAS Number	26807-65-8
Formula	C16H16ClN3O3S
Molar mass	365.835 g/mol

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