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|Appearance:||White Crystalline Powder||Protein Binding:||71–79%|
|Biological Half-life:||14–18 Hours||Shipment::||FedEx, TNT, EMS, DHL.UPS,EUB|
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Indapamide Pharmaceutical Intermediates Thiazide-like Diuretic Drug
Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment ofhypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.
Form and composition
Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets.It is now also available in SR (sustained release) form.
Hypertension and edema due to congestive heart failure. Indapamide has been proven in the HYVET trial to reduce stroke and all cause mortality when given with or without to people over the age of 80 for the treatment of hypertension.
Other uses for this medicine
Indapamide also is used to treat swelling and fluid retention caused by various medical conditions other than heart disease. Talk to your doctor about the possible risks of using this medicine for your condition.
Dosage and administration
The adult dosage is 1.25 to 5 mg, orally and once daily, usually in the morning.
Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe kidney failure, hepatic encephalopathy or severe liver failure, and a low blood potassium level.
There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding.
Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave-burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).
Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.
Commonly reported adverse events are hypokalemia (low potassium levels), fatigue, orthostatic hypotension (blood pressure decrease on standing up) and allergic manifestations.
Symptoms of overdosage would be those associated with a diuretic effect, i.e. electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting electrolyte abnormalities.
Do NOT use indapamide if
you are allergic to any ingredient in indapamide or to a sulfonamide medicine (eg, sulfamethoxazole)
you are unable to urinate
you are taking ketanserin
|Systematic (IUPAC) name||4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoyl-benzamide|
|Biological half-life||14–18 hours|
|Molar mass||365.835 g/mol|
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