Prilocaine Local Anesthetic Pharmaceutical Intermediates Citanest Dermal Anesthesia CAS 721-50-6

Prilocaine Local Anesthetic Citanest Dermal Anesthesia Raw Powder CAS 721-50-6

Prilocaine (/ˈpraɪləˌkeɪn/) is a local anesthetic of the amino amide type first prepared by Claes Tegnerand Nils Löfgren. In its injectable form (trade name Citanest), it is often used in dentistry.

It is also often combined with lidocaine as a topical preparation for dermal anesthesia (lidocaine/prilocaine orEMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA).

Contraindications

In some patients, ortho-toluidine, a metabolite of prilocaine, may cause methemoglobinemia, which may be treated with methylene blue. Prilocaine may also be contraindicated in people with sickle cell anemia,anemia, or symptomatic hypoxia.

People with pseudocholinesterase deficiency may have difficulty metabolizing this anesthetic.

prilocaine; Citanest relatively short- to moderate-acting local anaesthetic agent of low systemic toxicity, similar tobut less vasodilatory than lidocaine; maximum safe dose = 400mg for a 70-kg adult; should not be used onpregnant/lactating women as its metabolites can cause fetal/infant methaemoglobinaemia; avoid use on patients withsevere/untreated hypertension or severe heart disease; dosage should be reduced for elderly or debilitated patients, or thosewith hepatic or renal impairment; high strengths may cause ocular toxicity (see local anaesthetic (LA) administration,pregnancy; Table 1 and Table 2)

Table 1: Maximum safe doses of plain local anaesthetic agents (for 70Kg adult in 24 hours)

Table 2: Calculation of the combined maximum safe doses (MSDs) of plain local anaesthetic agents

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