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| MW: | 220.311 | MF: | C13H20N2O |
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| Appearance: | White Powder | Metabolism: | Hepatic And Renal |
| Protein Binding: | 55% | Biological Half-life: | 10-150 Minutes, Longer With Impaired Hepatic Or Renal Function |
| Email: | Tonyraws810@gmail.com | Whatsapp: | 86-15871352379 |
| Wickr: | Tonyraws | ||
| High Light: | raw pharmaceutical materials,raw materials for pharmaceutical products |
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Prilocaine Local Anesthetic Citanest Dermal Anesthesia Raw Powder CAS 721-50-6
Prilocaine (/ˈpraɪləˌkeɪn/) is a local anesthetic of the amino amide type first prepared by Claes Tegnerand Nils Löfgren. In its injectable form (trade name Citanest), it is often used in dentistry.
It is also often combined with lidocaine as a topical preparation for dermal anesthesia (lidocaine/prilocaine orEMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA).
Contraindications
In some patients, ortho-toluidine, a metabolite of prilocaine, may cause methemoglobinemia, which may be treated with methylene blue. Prilocaine may also be contraindicated in people with sickle cell anemia,anemia, or symptomatic hypoxia.
People with pseudocholinesterase deficiency may have difficulty metabolizing this anesthetic.
prilocaine; Citanest relatively short- to moderate-acting local anaesthetic agent of low systemic toxicity, similar tobut less vasodilatory than lidocaine; maximum safe dose = 400mg for a 70-kg adult; should not be used onpregnant/lactating women as its metabolites can cause fetal/infant methaemoglobinaemia; avoid use on patients withsevere/untreated hypertension or severe heart disease; dosage should be reduced for elderly or debilitated patients, or thosewith hepatic or renal impairment; high strengths may cause ocular toxicity (see local anaesthetic (LA) administration,pregnancy; Table 1 and Table 2)
Table 1: Maximum safe doses of plain local anaesthetic agents (for 70Kg adult in 24 hours)
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Table 1: Maximum safe doses of plain local anaesthetic agents (for 70Kg adult in 24 hours)
Agent (brand name) |
Maximum safe dose (70-kg adult) | Dose per kg of body mass |
| Lidocaine (Xylocaine) | 200mg | 3mg/kg |
| Bupivacaine (Marcain) | 150mg | 2mg/kg |
| Levo-bupivacaine (Chirocaine) | 150mg | 2mg/kg |
| Mepivacaine (Scandonest) | 400mg | 6mg/kg |
| Prilocaine (Citanest) | 400mg | 6mg/kg |
| Ropivacaine (Naropin) | 250mg | 3.5mg/kg |
Table 2: Calculation of the combined maximum safe doses (MSDs) of plain local anaesthetic agents
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Table 2: Calculation of the combined maximum safe doses (MSDs) of plain local anaesthetic agents
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Mass of drugadministered | Amount of drugs administered in relation toproportional MSDs | Percentage ofcombined MSD |
| e.g. 70-kg adult | |||
| Agent 1 6mL lidocaine2% |
120mg | Equivalent to (120/200) × 100% = 60% of MSDlidocaine | 77% |
| Agent 2 5mL bupivacaine0.5% |
25mg | Equivalent to (25/150) × 100% = 17% of MSDbupivacaine | |
| e.g. 40-kg child | |||
| Agent 1 4mL lidocaine2% |
80mg | Equivalent to (80/120) × 100% = 77% of MSDlidocaine | 89.5% |
| Agent 2 2mL bupivacaine0.5% |
10mg | Equivalent to (10/80) × 100% = 12.5% of MSDbupivacaine | |
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Where more than one anaesthetic agent is injected in order to achieve both rapid anaesthesia and prolonged postoperativepain relief, the proportional MSD of each of the anaesthetic agents should be calculated, in order not to exceed thecombined MSD.
The calculation is the product of the patient's body mass, the percentage mass of the individual anaesthetic agent and thetotal volume used of each local anaesthetic drug.
In the examples cited in this table, safe doses of anaesthesia would have been administered, as the combined doses ofeach anaesthetic does not exceed 100%. |
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